Journal
ANTIOXIDANTS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/antiox10030377
Keywords
natural antioxidants; miRNAs; eNOS; SIRT1; endothelial dysfunction
Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2019R1A2C1010536]
- National Research Foundation of Korea [2019R1A2C1010536] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Natural antioxidants play a crucial role in combating cardiovascular diseases, potentially exerting cardioprotective effects through various mechanisms. Research suggests that miRNAs are key players in regulating oxidative stress in cardiovascular diseases, affecting endothelial function by targeting eNOS and SIRT1.
Cardiovascular diseases (CVDs) are the most common cause of morbidity and mortality worldwide. The potential benefits of natural antioxidants derived from supplemental nutrients against CVDs are well known. Remarkably, natural antioxidants exert cardioprotective effects by reducing oxidative stress, increasing vasodilation, and normalizing endothelial dysfunction. Recently, considerable evidence has highlighted an important role played by the synergistic interaction between endothelial nitric oxide synthase (eNOS) and sirtuin 1 (SIRT1) in the maintenance of endothelial function. To provide a new perspective on the role of natural antioxidants against CVDs, we focused on microRNAs (miRNAs), which are important posttranscriptional modulators in human diseases. Several miRNAs are regulated via the consumption of natural antioxidants and are related to the regulation of oxidative stress by targeting eNOS and/or SIRT1. In this review, we have discussed the specific molecular regulation of eNOS/SIRT1-related endothelial dysfunction and its contribution to CVD pathologies; furthermore, we selected nine different miRNAs that target the expression of eNOS and SIRT1 in CVDs. Additionally, we have summarized the alteration of miRNA expression and regulation of activities of miRNA through natural antioxidant consumption.
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