An Update on Self-Amplifying mRNA Vaccine Development

This review will explore the four major pillars required for design and development of an saRNA vaccine: Antigen design, vector design, non-viral delivery systems, and manufacturing (both saRNA and lipid nanoparticles (LNP)). We report on the major innovations, preclinical and clinical data reported in the last five years and will discuss future prospects.

Automated summary

This review explores the four major pillars required for design and development of an saRNA vaccine, discussing antigen design, vector design, non-viral delivery systems, and manufacturing. It reports on major innovations, preclinical and clinical data from the last five years, and provides insights into future prospects.