Journal
VACCINES
Volume 9, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/vaccines9030199
Keywords
Enterovirus A71; hand; foot and mouth disease (HFMD); vaccine; Sinovac
Categories
Funding
- National Institutes of Health [R01 GM126833]
- Research Center for Emerging Viral Infections from The Featured Areas Research Center Program
- Ministry of Science and Technology, Taiwan [MOST 108-3017-F 182-001]
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Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina, with potential neurological complications and death. Vaccination is the most efficient way to control virus infection, with multiple types of vaccines currently in development and use.
Enterovirus A71 (EV-A71) is a major causative agent of hand, foot, and mouth disease (HFMD) and herpangina. Moreover, EV-A71 infection can lead to neurological complications and death. Vaccination is the most efficient way to control virus infection. There are currently three inactivated, whole EV-A71 vaccines licensed by the China NMPA (National Medical Products Administration). Several other types of vaccines, such as virus-like particles and recombinant VP1 (capsid protein), are also under development. In this review, we discuss recent advances in the development of EV-A71 vaccines.
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