Journal
MICROBIAL GENOMICS
Volume 7, Issue 3, Pages -Publisher
MICROBIOLOGY SOC
DOI: 10.1099/mgen.0.000528
Keywords
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Funding
- Horse Trust [G1606]
- Estate of Paul Mellon Foundation
- Alice Noakes Memorial Charitable Trust
- Ivo Trust
- Elise Pilkington Charitable Trust
- European Breeders Fund
- Margaret Giffen Charitable Trust
- Payne Gallwey Charitable Trust
- Stafford Trust
- Marjorie Coote Animal Charity Trust
- Beryl Evetts and Robert Luff Animal Welfare Trust
- Anne Duchess of Westminster's Charitable Trust
- Sir Peter O'Sullevan Charitable Trust
- Horserace Betting Levy Board
- Racehorse Owners Association
- Thoroughbred Breeders' Association
- Petplan Charitable Trust [S19-741-780]
- New Zealand Equine Research Foundation
- Wellcome Trust [098051]
- Grayson Jockey Club Research Foundation
- Keeneland Association Endowment
- Tattersalls
- Serth and Gates Charity
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This study analyzed and visualized phylogenomic and epidemiological data of 670 isolates of Streptococcus equi from 19 countries, revealing the genetic relationships and transmission events of the equine disease strangles in horse populations worldwide. The data highlight the international importance of strangles and emphasize the need for recognition and prevention strategies.
The equine disease strangles, which is characterized by the formation of abscesses in the lymph nodes of the head and neck, is one of the most frequently diagnosed infectious diseases of horses around the world. The causal agent, Streptococcus equi subspecies equi, establishes a persistent infection in approximately 10 % of animals that recover from the acute disease. Such ?carrier? animals appear healthy and are rarely identified during routine veterinary examinations pre- purchase or transit, but can transmit S. equi to na?ve animals initiating new episodes of disease. Here, we report the analysis and visualization of phylogenomic and epidemiological data for 670 isolates of S. equi recovered from 19 different countries using a new core- genome multilocus sequence typing (cgMLST) web bioresource. Genetic relationships among all 670 S. equi isolates were determined at high resolution, revealing national and international transmission events that drive this endemic disease in horse populations throughout the world. Our data argue for the recognition of the international importance of strangles by the Office International des ?pizooties to highlight the health, welfare and economic cost of this disease. The Pathogenwatch cgMLST web bioresource described herein is available for tailored genomic analysis of populations of S. equi and its close relative S. equi subspecies zooepidemicus that are recovered from horses and other animals, including humans, throughout the world. This article contains data hosted by Microreact.
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