Journal
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fbioe.2021.624503
Keywords
5-hydroxytryptophan; tryptophan hydroxylase; L-trp; biosynthesis; tetrahydrobiopterin
Funding
- Shanghai Sailing Program [20YF1433500]
- National Key R&D Program of China [2018YFC1604305]
- Shanghai Agriculture Applied Technology Development Program, China [2019-02-08-00-07-F01152]
- Natural Science Foundation of China [31871757]
- Shanghai Technical Standard Program, China [18DZ2200200]
- Shanghai Engineering Research Center of food microbiology program [19DZ22 81100]
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5-hydroxytryptophan (5-HTP) plays a crucial role in regulating various physiological functions and is used in treating depression, insomnia, and other diseases. Due to inadequate natural extraction methods, increasing production efficiency through enzyme directed evolution and substrate supply pathways has become necessary to meet market demands.
5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack of effective biosynthesis methods, 5-HTP is mainly obtained by natural extraction, which has been unable to meet the needs of the market. Through the directed evolution of enzymes and the introduction of substrate supply pathways, 5-HTP biosynthesis and yield increase have been realized. This review provides examples that illustrate the production mode of 5-HTP and the latest progress in microbial synthesis.
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