Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.599065
Keywords
cofilin; actin-binding protein; apoptosis; migration; cancer metastasis
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Funding
- Chinese Medicine Inheritance and Innovation 100 Million Talent Project
- Three-year Action Plan Project of Shanghai Traditional Chinese Medicine Development [ZY(2018-2020)-CCCX-200401]
- Shanghai Municipal Population and Family Planning Commission Excellent Youth Talent Training Program [2018YQ11]
- National Natural Science Foundation [81674071, 81674074, 81973953]
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Cofilin is a protein that plays a crucial role in cancer metastasis by regulating cytoskeletal reorganization and other processes. Clinical studies have explored the relationship between cofilin, tumor cells apoptosis, and cofilin-related miRNAs.
Cofilin is an actin-binding protein that regulates filament dynamics and depolymerization. The over-expression of cofilin is observed in various cancers, cofilin promotes cancer metastasis by regulating cytoskeletal reorganization, lamellipodium formation and epithelial-to-mesenchymal transition. Clinical treatment of cancer regarding cofilin has been explored in aspects of tumor cells apoptosis and cofilin related miRNAs. This review addresses the structure and phosphorylation of cofilin and describes recent findings regarding the function of cofilin in regulating cancer metastasis and apoptosis in tumor cells.
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