Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.630161
Keywords
primary cilium; cerebral cortex; ciliopathy; signaling; radial glial cells; corpus callosum
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/P00122X/1]
- Simons Initiative for the Developing Brain [SFARI - 9569385]
- BBSRC [BB/P00122X/1] Funding Source: UKRI
Ask authors/readers for more resources
The formation of the cerebral cortex, a complex process involving various types of neurons and complex connections, is crucial for advanced neural functions. Recent studies have linked cilia to processes such as neurogenesis and neuronal migration during cortex development.
The primary cilium, a microtubule based organelle protruding from the cell surface and acting as an antenna in multiple signaling pathways, takes center stage in the formation of the cerebral cortex, the part of the brain that performs highly complex neural tasks and confers humans with their unique cognitive capabilities. These activities require dozens of different types of neurons that are interconnected in complex ways. Due to this complexity, corticogenesis has been regarded as one of the most complex developmental processes and cortical malformations underlie a number of neurodevelopmental disorders such as intellectual disability, autism spectrum disorders, and epilepsy. Cortical development involves several steps controlled by cell-cell signaling. In fact, recent findings have implicated cilia in diverse processes such as neurogenesis, neuronal migration, axon pathfinding, and circuit formation in the developing cortex. Here, we will review recent advances on the multiple roles of cilia during cortex formation and will discuss the implications for a better understanding of the disease mechanisms underlying neurodevelopmental disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available