Related references
Note: Only part of the references are listed.Defining the subcellular distribution and metabolic channeling of phosphatidylinositol
Joshua G. Pemberton et al.
JOURNAL OF CELL BIOLOGY (2020)
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
Spencer A. Freeman et al.
SCIENCE (2020)
Phagocytosis of Necrotic Debris at Sites of Injury and Inflammation
Johannes Westman et al.
FRONTIERS IN IMMUNOLOGY (2020)
The cell biology of inflammation: From common traits to remarkable immunological adaptations
Helen Weavers et al.
JOURNAL OF CELL BIOLOGY (2020)
Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells
Cynthia Lopez-Haber et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment
Chunguang Ren et al.
DEVELOPMENTAL CELL (2019)
PTENα promotes neutrophil chemotaxis through regulation of cell deformability
Yunqiao Li et al.
BLOOD (2019)
THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE
Pei Xiong Liew et al.
PHYSIOLOGICAL REVIEWS (2019)
The Msp Protein of Treponema denticola Interrupts Activity of Phosphoinositide Processing in Neutrophils
Megan M. Jones et al.
INFECTION AND IMMUNITY (2019)
Phagolysosome resolution requires contacts with the endoplasmic reticulum and phosphatidylinositol-4-phosphate signalling
Roni Levin-Konigsberg et al.
NATURE CELL BIOLOGY (2019)
A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product
Brady D. Goulden et al.
JOURNAL OF CELL BIOLOGY (2019)
Direct analysis of PI(3,4,5)P3 using liquid chromatography electrospray ionization tandem mass spectrometry
Hai H. Bui et al.
ANALYTICAL BIOCHEMISTRY (2018)
Genetically encoded lipid biosensors
Rachel C. Wills et al.
MOLECULAR BIOLOGY OF THE CELL (2018)
SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes
James P. Zewe et al.
ELIFE (2018)
Recent advances in the optical control of protein function through genetic code expansion
Taylor Courtney et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease
John E. Burke
MOLECULAR CELL (2018)
FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis
Laura Chan Wah Hak et al.
NATURE CELL BIOLOGY (2018)
Neutrophils: New insights and open questions
Klaus Ley et al.
SCIENCE IMMUNOLOGY (2018)
PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
Mouhannad Malek et al.
MOLECULAR CELL (2017)
The C-terminal region of the major outer sheath protein of Treponema denticola inhibits neutrophil chemotaxis
M. M. Jones et al.
MOLECULAR ORAL MICROBIOLOGY (2017)
Neutrophils and Immunity: From Bactericidal Action to Being Conquered
Tie-Shan Teng et al.
JOURNAL OF IMMUNOLOGY RESEARCH (2017)
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KIIα, Inhibits the Growth of Breast Cancer Cells
Jiangmei Li et al.
CANCER RESEARCH (2017)
Bisperoxovandium (pyridin-2-squaramide) targets both PTEN and ERK1/2 to confer neuroprotection
Zhi-Feng Zhang et al.
BRITISH JOURNAL OF PHARMACOLOGY (2017)
Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes
Hongzhao Li et al.
JOURNAL OF IMMUNOLOGY (2016)
Locally excitable Cdc42 signals steer cells during chemotaxis
Hee Won Yang et al.
NATURE CELL BIOLOGY (2016)
Phosphatidylinositol 3,5-Bisphosphate-Rich Membrane Domains in Endosomes and Lysosomes
Sho Takatori et al.
TRAFFIC (2016)
Comprehensive and Quantitative Analysis of Polyphosphoinositide Species by Shotgun Lipidomics Revealed Their Alterations in db/db Mouse Brain
Chunyan Wang et al.
ANALYTICAL CHEMISTRY (2016)
Leading from the Back: The Role of the Uropod in Neutrophil Polarization and Migration
Laurel E. Hind et al.
DEVELOPMENTAL CELL (2016)
The life cycle of phagosomes: formation, maturation, and resolution
Roni Levin et al.
IMMUNOLOGICAL REVIEWS (2016)
A phosphoinositide conversion mechanism for exit from endosomes
Katharina Ketel et al.
NATURE (2016)
Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE
G. Carmona et al.
ONCOGENE (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
Human neutrophils in auto-immunity
Nathalie Thieblemont et al.
SEMINARS IN IMMUNOLOGY (2016)
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages
Johnathan Canton et al.
NATURE COMMUNICATIONS (2016)
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
Daniel M. Houslay et al.
SCIENCE SIGNALING (2016)
The role of neutrophils in immune dysfunction during severe inflammation
Pieter H. C. Leliefeld et al.
CRITICAL CARE (2016)
Neutrophils in cancer: neutral no more
Seth B. Coffelt et al.
NATURE REVIEWS CANCER (2016)
GABARAP-mediated targeting of PI4K2A/PI4KII to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion
Joseph Albanesi et al.
AUTOPHAGY (2015)
Phosphoinositides and host-pathogen interactions
Javier Pizarro-Cerda et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
Polyphosphoinositide binding domains: Key to inositol lipid biology
Gerald R. V. Hammond et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
Phosphoinositides in phagocytosis and macropinocytosis
Roni Levin et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
ER contact sites direct late endosome transport
Ruud H. Wijdeven et al.
BIOESSAYS (2015)
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils
Kun Gao et al.
JOURNAL OF CELL SCIENCE (2015)
Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis
Andreas Jeschke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
Joachim Moser von Filseck et al.
SCIENCE (2015)
The Phosphoinositide-Gated Lysosomal Ca2+ Channel, TRPML1, Is Required for Phagosome Maturation
Roya M. Dayam et al.
TRAFFIC (2015)
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor
Spencer A. Freeman et al.
NATURE COMMUNICATIONS (2015)
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins
Daniel Schlam et al.
NATURE COMMUNICATIONS (2015)
Lamellipodin promotes actin assembly by clustering Ena/VASP proteins and tethering them to actin filaments
Scott D. Hansen et al.
ELIFE (2015)
Endophilin marks and controls a clathrin-independent endocytic pathway
Emmanuel Boucrot et al.
NATURE (2015)
Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns (3,4)P2
Kiyomi Nigorikawa et al.
PLOS ONE (2015)
Identification of Inhibitors of Inositol 5-Phosphatases through Multiple Screening Strategies
Michelle Pirruccello et al.
ACS CHEMICAL BIOLOGY (2014)
Phosphatidylinositol 3,5-bisphosphate: Low abundance, high significance
Amber J. McCartney et al.
BIOESSAYS (2014)
The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton
Baoyu Chen et al.
CELL (2014)
The Legionella longbeachae Icm/Dot Substrate SidC Selectively Binds Phosphatidylinositol 4-Phosphate with Nanomolar Affinity and Promotes Pathogen Vacuole-Endoplasmic Reticulum Interactions
Stephanie Dolinsky et al.
INFECTION AND IMMUNITY (2014)
A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis
Chinmay R. Surve et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels
Naveen Bojjireddy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
Gerald R. V. Hammond et al.
JOURNAL OF CELL BIOLOGY (2014)
Phagosome maturation in polarized macrophages
Johnathan Canton
JOURNAL OF LEUKOCYTE BIOLOGY (2014)
Genetically Encoded Optochemical Probes for Simultaneous Fluorescence Reporting and Light Activation of Protein Function with Two-Photon Excitation
Ji Luo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
Matthias Krause et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization
Brittany D. Wright et al.
NEURON (2014)
The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer
Julius Semenas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation
Adriana R. Mantegazza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
PIKfyve Inhibition Interferes with Phagosome and Endosome Maturation in Macrophages
Grace H. E. Kim et al.
TRAFFIC (2014)
The Cellular and Physiological Functions of the Lowe Syndrome Protein OCRL1
Zenobia B. Mehta et al.
TRAFFIC (2014)
The Multifaceted Functions of Neutrophils
Tanya N. Mayadas et al.
Annual Review of Pathology-Mechanisms of Disease (2013)
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
Ralph Fritsch et al.
CELL (2013)
A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis
Mohammad Samie et al.
DEVELOPMENTAL CELL (2013)
Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration
Angela Oppelt et al.
EMBO REPORTS (2013)
Diacylglycerol Kinases Terminate Diacylglycerol Signaling during the Respiratory Burst Leading to Heterogeneous Phagosomal NADPH Oxidase Activation
Daniel Schlam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo
Ah-Lai Law et al.
JOURNAL OF CELL BIOLOGY (2013)
Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3
Laure Gambardella et al.
JOURNAL OF IMMUNOLOGY (2013)
Integrin Regulation during Leukocyte Recruitment
Jan Herter et al.
JOURNAL OF IMMUNOLOGY (2013)
Phosphatidic acid is required for the constitutive ruffling and macropinocytosis of phagocytes
Michal Bohdanowicz et al.
MOLECULAR BIOLOGY OF THE CELL (2013)
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
York Posor et al.
NATURE (2013)
PHOSPHOINOSITIDES: TINY LIPIDS WITH GIANT IMPACT ON CELL REGULATION
Tamas Balla
PHYSIOLOGICAL REVIEWS (2013)
ROLE OF PHOSPHOLIPIDS IN ENDOCYTOSIS, PHAGOCYTOSIS, AND MACROPINOCYTOSIS
Michal Bohdanowicz et al.
PHYSIOLOGICAL REVIEWS (2013)
Treponema denticola Major Outer Sheath Protein Impairs the Cellular Phosphoinositide Balance That Regulates Neutrophil Chemotaxis
Michelle B. Visser et al.
PLOS ONE (2013)
Regulation of the NADPH Oxidase and Associated Ion Fluxes During Phagocytosis
Paula Nunes et al.
TRAFFIC (2013)
The lysosome: from waste bag to potential therapeutic target
Hanna Appelqvist et al.
JOURNAL OF MOLECULAR CELL BIOLOGY (2013)
Apical targeting of the formin Diaphanous in Drosophila tubular epithelia
Tal Rousso et al.
ELIFE (2013)
Acquired PIK3CA amplification causes resistance to selective phosphoinositide 3-kinase inhibitors in breast cancer
L-Y Huw et al.
ONCOGENESIS (2013)
The Cell Biology of Phagocytosis
Ronald S. Flannagan et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 (2012)
STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis
Paula Nunes et al.
CURRENT BIOLOGY (2012)
12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Stefan Uderhardt et al.
IMMUNITY (2012)
The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish
Pui-ying Lam et al.
JOURNAL OF CELL SCIENCE (2012)
Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling
Michal Bohdanowicz et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Therapeutic Potential of SH2 Domain-Containing Inositol-5′-Phosphatase 1 (SHIP1) and SHIP2 Inhibition in Cancer
Gwenny M. Fuhler et al.
MOLECULAR MEDICINE (2012)
Rapid and orthogonal logic gating with a gibberellin-induced dimerization system
Takafumi Miyamoto et al.
NATURE CHEMICAL BIOLOGY (2012)
Optogenetic control of phosphoinositide metabolism
Olof Idevall-Hagren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity
Gerald R. V. Hammond et al.
SCIENCE (2012)
Phosphatidylinositol-3,5-Bisphosphate: No Longer the Poor PIP2
Cheuk Y. Ho et al.
TRAFFIC (2012)
How nascent phagosomes mature to become phagolysosomes
Gregory D. Fairn et al.
TRENDS IN IMMUNOLOGY (2012)
Stiffness and heterogeneity of the pulmonary endothelial glycocalyx measured by atomic force microscopy
Ryan O'Callaghan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2011)
Rac regulates PtdInsP3 signaling and the chemotactic compass through a redox-mediated feedback loop
Jan W. P. Kuiper et al.
BLOOD (2011)
MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between
Markus Babst
CURRENT OPINION IN CELL BIOLOGY (2011)
A PLCβ/PI3Kγ-GSK3 Signaling Pathway Regulates Cofilin Phosphatase Slingshot2 and Neutrophil Polarization and Chemotaxis
Wenwen Tang et al.
DEVELOPMENTAL CELL (2011)
Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity
Bebhinn Treanor et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
PTEN Negatively Regulates Engulfment of Apoptotic Cells by Modulating Activation of Rae GTPase
Subhanjan Mondal et al.
JOURNAL OF IMMUNOLOGY (2011)
Phagosome dynamics during phagocytosis by neutrophils
Pontus Nordenfelt et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2011)
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry
Jonathan Clark et al.
NATURE METHODS (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1
Vassilis Koronakis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization
Tasuku Ueno et al.
SCIENCE SIGNALING (2011)
c-Abl, Lamellipodin, and Ena/VASP Proteins Cooperate in Dorsal Ruffling of Fibroblasts and Axonal Morphogenesis
Magdalene Michael et al.
CURRENT BIOLOGY (2010)
Mechanisms of force generation and force transmission during interstitial leukocyte migration
Joerg Renkawitz et al.
EMBO REPORTS (2010)
An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells
Santos Manes et al.
FASEB JOURNAL (2010)
Integrin-Induced PIP5K1C Kinase Polarization Regulates Neutrophil Polarization, Directionality, and In Vivo Infiltration
Wenwen Xu et al.
IMMUNITY (2010)
Differential Regulation of Phospholipase C-β2 Activity and Membrane Interaction by Gαq, Gβ1γ2, and Rac2
Orit Gutman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Kodi S. Ravichandran
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
SHIP1 Inhibition Increases Immunoregulatory Capacity and Triggers Apoptosis of Hematopoietic Cancer Cells
Robert Brooks et al.
JOURNAL OF IMMUNOLOGY (2010)
Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
Thomas Wollert et al.
NATURE (2010)
Periodontitis: a polymicrobial disruption of host homeostasis
Richard P. Darveau
NATURE REVIEWS MICROBIOLOGY (2010)
Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling
Zsofia Szentpetery et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1)
Ashwini Mishra et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome
Xian-ping Dong et al.
NATURE COMMUNICATIONS (2010)
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P2
Gerald R. V. Hammond et al.
BIOCHEMICAL JOURNAL (2009)
The BAR Domain Superfamily: Membrane-Molding Macromolecules
Adam Frost et al.
CELL (2009)
Leading a Sheltered Life: Intracellular Pathogens and Maintenance of Vacuolar Compartments
Yadunanda Kumar et al.
CELL HOST & MICROBE (2009)
Neutrophils Establish Rapid and Robust WAVE Complex Polarity in an Actin-Dependent Fashion
Arthur Millius et al.
CURRENT BIOLOGY (2009)
Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila
Eva Brombacher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis
Gregory D. Fairn et al.
JOURNAL OF CELL BIOLOGY (2009)
Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification
Ge-Hong Sun-Wada et al.
JOURNAL OF CELL SCIENCE (2009)
Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation
Bara Sarraj et al.
JOURNAL OF IMMUNOLOGY (2009)
Activation of the WAVE Complex by Coincident Signals Controls Actin Assembly
Andres M. Lebensohn et al.
MOLECULAR CELL (2009)
Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease
Heather J. McCrea et al.
PHYSIOLOGY (2009)
A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN
Meghdad Rahdar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease
Aurore Saudemont et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110γ
Barbara Kurig et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Signaling Mechanisms Underlying Cell Polarity and Chemotaxis
Fei Wang
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
FcγR-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome
Wei Tian et al.
BLOOD (2008)
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110α
Eli R. Zunder et al.
CANCER CELL (2008)
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse
Natsuko Jin et al.
EMBO JOURNAL (2008)
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7
Raul Rojas et al.
JOURNAL OF CELL BIOLOGY (2008)
PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP
Bryan Heit et al.
JOURNAL OF CELL SCIENCE (2008)
Sequential binding of cytosolic phox complex to phagosomes through regulated adaptor proteins: Evaluation using the novel monomeric kusabira-green system and live imaging of phagocytosis
Takehiko Ueyama et al.
JOURNAL OF IMMUNOLOGY (2008)
ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality
Diego Sbrissa et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells
Teruko Nishioka et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils
Bryan Heit et al.
NATURE IMMUNOLOGY (2008)
Phagosome maturation: going through the acid test
Jason M. Kinchen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Synthetic Activation of Endogenous PI3K and Rac Identifies an AND-Gate Switch for Cell Polarization and Migration
Takanari Inoue et al.
PLOS ONE (2008)
Type I phosphatidylinositol 4-phosphate 5-kinase controls neutrophil polarity and directional movement
Rosa Ana Lacalle et al.
JOURNAL OF CELL BIOLOGY (2007)
Type Iγ PIP kinase is a novel uropod component that regulates rear retraction during neutrophil chemotaxis
Mary A. Lokuta et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
A critical role of protein kinase Cδ activation loop phosphorylation in formyl-methionyl-leucyl-phenylalanine-induced phosphorylation of p47phox and rapid activation of nicotinamide adenine dinucleotide phosphate oxidase
Ni Cheng et al.
JOURNAL OF IMMUNOLOGY (2007)
Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains
Debasis Manna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling
Chun-Chun Li et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Functional architecture of the retromer cargo-recognition complex
Aitor Hierro et al.
NATURE (2007)
Phagocytosis and antigen presentation in dendritic cells
Ariel Savina et al.
IMMUNOLOGICAL REVIEWS (2007)
Leukocyte PI3Kγ and PI3Kδ have temporally distinct roles for leukocyte recruitment in vivo
Lixin Liu et al.
BLOOD (2007)
The p110δ isoform of PI 3-kinase negatively controls RhoA and PTEN
Evangelia A. Papakonstanti et al.
EMBO JOURNAL (2007)
Differential redox regulation within the PTP superfamily
Sarah H. Ross et al.
CELLULAR SIGNALLING (2007)
Chemoattractants and chemorepellents act by inducing opposite polarity in phospholipase C and PI3-kinase signaling
Ineke Keizer-Gunnink et al.
JOURNAL OF CELL BIOLOGY (2007)
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
Kulandayan K. Subramanian et al.
BLOOD (2007)
Chemotaxis in the absence of PIP3 gradients
Oliver Hoeller et al.
CURRENT BIOLOGY (2007)
Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium
Kosuke Takeda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane
Irmgard Hofmann et al.
CURRENT BIOLOGY (2007)
Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor βIII spectrin
Marie Johansson et al.
JOURNAL OF CELL BIOLOGY (2007)
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
Natalie Andrew et al.
NATURE CELL BIOLOGY (2007)
An actin-based wave generator organizes cell motility
Orion D. Weiner et al.
PLOS BIOLOGY (2007)
The WASP-WAVE protein network: connecting the membrane to the cytoskeleton
Tadaomi Takenawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Control of cell polarity and motility by the PtdIns(3,4,5)P-3 phosphatase SHIP1
Miki Nishio et al.
NATURE CELL BIOLOGY (2007)
PI(3)K gamma has an important context-dependent role in neutrophil chemokinesis
G. John Fergus et al.
NATURE CELL BIOLOGY (2007)
Rapid chemically induced changes of Ptdlns(4,5)P2 gate KCNQ ion channels
Byung-Chang Suh et al.
SCIENCE (2006)
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
Won Do Heo et al.
SCIENCE (2006)
Phosphatidylinositol 4-kinase IIIβ regulates the transport of ceramide between the endoplasmic reticulum and Golgi
Balazs Toth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction
Vitaliy Y. Gorbatyuk et al.
MOLECULAR CELL (2006)
Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells
Peter Varnai et al.
JOURNAL OF CELL BIOLOGY (2006)
Gβγs and the Ras binding domain of p110γ are both important regulators of PI(3)Kγ signalling in neutrophils
Sabine Suire et al.
NATURE CELL BIOLOGY (2006)
Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting
N. Fili et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum
Stacey S. Willard et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2006)
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis
Yuya Kunisaki et al.
JOURNAL OF CELL BIOLOGY (2006)
Receptor activation alters inner surface potential during phagocytosis
Tony Yeung et al.
SCIENCE (2006)
Class IA phosphatidylinositide 3-kinases, rather than p110γ, regulate formyl-methionyl-leucyl-phenylalanine-stimulated chemotaxis and superoxide production in differentiated neutrophil-like PLB-985 cells
Isaline Boulven et al.
JOURNAL OF IMMUNOLOGY (2006)
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
Zachary A. Knight et al.
CELL (2006)
Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells
Gerald R. V. Hammond et al.
JOURNAL OF CELL SCIENCE (2006)
Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium:: A quantitative in vivo analysis by inhibition of PI3-kinase
HM Loovers et al.
MOLECULAR BIOLOGY OF THE CELL (2006)
Modulation of human neutrophil functions in vitro by Treponema denticola major outer sheath protein
BP Thomas et al.
INFECTION AND IMMUNITY (2006)
Neutrophils and immunity: challenges and opportunities
C Nathan
NATURE REVIEWS IMMUNOLOGY (2006)
The Vac 14p-Fig4p complex acts independently of Vac7p and couples PI,5P2 synthesis and turnover
JE Duex et al.
JOURNAL OF CELL BIOLOGY (2006)
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis
OD Weiner et al.
PLOS BIOLOGY (2006)
Localised PtdIns(3,4,5)P3 or PtdIns(3,4)P2 at the phagocytic cup is required for both phagosome closure and Ca2+ signalling in HL60 neutrophils
S Dewitt et al.
JOURNAL OF CELL SCIENCE (2006)
A pharmacological map of the PI3-K family defines a role for p110 alpha in insulin signaling
Zachary A. Knight et al.
CELL (2006)
A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)
Erika Rosivatz et al.
ACS CHEMICAL BIOLOGY (2006)
Plasma membrane phosphoinositide organization by protein electrostatics
S McLaughlin et al.
NATURE (2005)
Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners
P Várnai et al.
JOURNAL OF CELL SCIENCE (2005)
A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling
JF Côté et al.
NATURE CELL BIOLOGY (2005)
Intracellular signalling controlling integrin activation in lymphocytes
T Kinashi
NATURE REVIEWS IMMUNOLOGY (2005)
An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways
T Inoue et al.
NATURE METHODS (2005)
Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
CC Scott et al.
JOURNAL OF CELL BIOLOGY (2005)
GEF means go: Turning on Rho GTPases with guanine nucleotide-exchange factors
KL Rossman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P
A Godi et al.
NATURE CELL BIOLOGY (2004)
Activation of type I phosphatidylinositol 4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42
PAO Weernink et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cutting edge:: Differential roles for phosphoinositide 3-kinases, p110γ and p110δ, in lymphocyte chemotaxis and homing
K Reif et al.
JOURNAL OF IMMUNOLOGY (2004)
Phospholipases D1 and D2 coordinately regulate macrophage phagocytosis
SS Iyer et al.
JOURNAL OF IMMUNOLOGY (2004)
Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells
R He et al.
JOURNAL OF IMMUNOLOGY (2004)
Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton
C Janetopoulos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The pleckstrin homology domain of phosphoinositide-specific phospholipase Cδ4 is not a critical determinant of the membrane localization of the enzyme
SB Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
TI-VAMP/VAMP7 is required for optimal phagocytosis of opsonised particles in macrophages
V Braun et al.
EMBO JOURNAL (2004)
Rac regulation of chemotaxis and morphogenesis in Dictyostelium
KC Park et al.
EMBO JOURNAL (2004)
Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high-curvature membranes and 3-phosphoinositides
J Carlton et al.
CURRENT BIOLOGY (2004)
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation
JH Lee et al.
JOURNAL OF CELL BIOLOGY (2004)
Superoxide production at phagosomal cup/phagosome through βI protein kinase C during FcγR-mediated phagocytosis in microglia
T Ueyama et al.
JOURNAL OF IMMUNOLOGY (2004)
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria
OV Vieira et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Lamellipodin, an EnaNASP ligand, is implicated in the regulation of lamellipodial dynamics
M Krause et al.
DEVELOPMENTAL CELL (2004)
PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
T Oikawa et al.
NATURE CELL BIOLOGY (2004)
Cell migration: Integrating signals from front to back
AJ Ridley et al.
SCIENCE (2003)
DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1
T Sanui et al.
BLOOD (2003)
Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade
I Vergne et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
JS Xu et al.
CELL (2003)
Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry
MR Wenk et al.
NATURE BIOTECHNOLOGY (2003)
Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis
HH Gu et al.
JOURNAL OF CELL BIOLOGY (2003)
Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells
YE Huang et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase
OV Vieira et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Rac2 regulation of phospholipase C-β2 activity and mode of membrane interactions in intact cells
D Illenberger et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Essential role of phosphoinositide 3-kinase δ in neutrophil directional movement
C Sadhu et al.
JOURNAL OF IMMUNOLOGY (2003)
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis
S Srinivasan et al.
JOURNAL OF CELL BIOLOGY (2003)
Elevation of oleate-activated phospholipase D activity during thymic atrophy
Y Lee et al.
IMMUNOLOGY (2002)
An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients
B Heit et al.
JOURNAL OF CELL BIOLOGY (2002)
Syntaxins 13 and 7 function at distinct steps during phagocytosis
RF Collins et al.
JOURNAL OF IMMUNOLOGY (2002)
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
S Eden et al.
NATURE (2002)
ERM proteins and merlin: Integrators at the cell cortex
A Bretscher et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration
N Yoshinaga-Ohara et al.
EXPERIMENTAL CELL RESEARCH (2002)
Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development
D Dormann et al.
CURRENT BIOLOGY (2002)
A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity
OD Weiner et al.
NATURE CELL BIOLOGY (2002)
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
F Wang et al.
NATURE CELL BIOLOGY (2002)
Myosin X is a downstream effector of PI(3)K during phagocytosis
D Cox et al.
NATURE CELL BIOLOGY (2002)
p59Hck isoform induces F-actin reorganization to form protrusions of the plasma membrane in a Cdc42- and Rac-dependent manner
S Carréno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Role of Rab5 in the recruitment of hVps34/p150 to the early endosome
JT Murray et al.
TRAFFIC (2002)
Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
S Funamoto et al.
CELL (2002)
Tumor suppressor PTEN mediates sensing of chemoattractant gradients
M Iijima et al.
CELL (2002)
A monoclonal antibody to visualize Ptdlns(3,4,5)P3 in cells
RY Chen et al.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2002)
Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and -independent components
TP Levine et al.
CURRENT BIOLOGY (2002)
Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis
M Hannigan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection
C Nasuhoglu et al.
ANALYTICAL BIOCHEMISTRY (2002)
Contrasting requirements for ubiquitylation during Fc receptor-mediated endocytosis and phagocytosis
JW Booth et al.
EMBO JOURNAL (2002)
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices
S Krugmann et al.
MOLECULAR CELL (2002)
Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
OV Vieira et al.
JOURNAL OF CELL BIOLOGY (2001)
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
FD Brown et al.
JOURNAL OF CELL BIOLOGY (2001)
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
RA Fratti et al.
JOURNAL OF CELL BIOLOGY (2001)
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
R Rohatgi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The PX domains of p47phox and p40phox bind to lipid products of Pl(3)K
F Kanai et al.
NATURE CELL BIOLOGY (2001)
Ptdlns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox
CD Ellson et al.
NATURE CELL BIOLOGY (2001)
Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fcγ receptor-mediated phagocytosis
JG Marshall et al.
JOURNAL OF CELL BIOLOGY (2001)
Role of Treponema denticola in periodontal diseases
MN Sela
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE (2001)
Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis
RJ Botelho et al.
JOURNAL OF CELL BIOLOGY (2000)
Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs
JK Klarlund et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Interaction of the Type Iα PIPkinase with phospholipase D:: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity
N Divecha et al.
EMBO JOURNAL (2000)
Localized Rac activation dynamics visualized in living cells
VS Kraynov et al.
SCIENCE (2000)
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4,5-bisphosphate
R Rohatgi et al.
JOURNAL OF CELL BIOLOGY (2000)
Interaction of the EEA1 FYVE finger with phosphatidylinositol 3-phosphate and early endosomes - Role of conserved residues
JM Gaullier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
A membrane-permeant ester of phosphatidylinositol 3,4,5-trisphosphate (PIP3) is an activator of human neutrophil migration
V Niggli
FEBS LETTERS (2000)
Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation
L Bajno et al.
JOURNAL OF CELL BIOLOGY (2000)
Involvement of the Arp2/3 complex in phagocytosis mediated by FcγR or CR3
RC May et al.
NATURE CELL BIOLOGY (2000)
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
E Hirsch et al.
SCIENCE (2000)
Roles of PLC-β2 and -β3 and PI3Kγ in chemoattractant-mediated signal transduction
Z Li et al.
SCIENCE (2000)
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
T Sasaki et al.
SCIENCE (2000)
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
G Servant et al.
SCIENCE (2000)
Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly
KF Tolias et al.
CURRENT BIOLOGY (2000)
Share Paper
