Journal
APPLIED MATERIALS TODAY
Volume 22, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apmt.2020.100929
Keywords
Mesoporous selenium nanoenzyme; Scavenging ROS; Targeting therapy; Local inflammatory injury; Sepsis
Categories
Funding
- National Natural Science Foundation of China [21877051, 81803027]
- Planned Item of Science and Technology of Guangdong Province [2016A020217011]
Ask authors/readers for more resources
The study developed a novel mesoporous selenium-hyaluronic acid nanoenzyme therapeutic system to target and eliminate ROS in inflammatory immune cells for treating local inflammation and sepsis injury, showing high activity, broad spectrum ROS elimination capacity, and enhanced targeting properties. In vivo experiments demonstrated significant improvements in survival rate and organ function in sepsis mouse models after treatment with this nanozyme system.
Excessive reactive oxygen species (ROS) is the main factor leading to high mortality in local inflammation and sepsis. Therefore, developing efficient ROS scavenger in pro-inflammatory immune cells is an urgent strategy for therapy local inflammatory and sepsis injury. Herein, we constructed a novel mesoporous selenium-hyaluronic acid nanoenzyme therapeutic system (MSe-HA NPs) for therapy local inflammatory and sepsis injury by targeting eliminate ROS in inflammatory macrophage. In detail manners, the high specific surface area of mesoporous selenium nanoenzyme exhibited ultra-high activity like glutathione peroxidase (GPx), which catalytic speed of H2O2 scavenging was increasing to 2.02 times compare with solid Se NPs. Moreover, the broad spectrum of ROS eliminating capacity further promoted ability of MSe NPs in eliminating various ROS. More interestingly, we found that choose HA as the modification not only endowed the MSe NPs targeting to inflammatory macrophage, but the ROS degradable property of HA could enhance the MSe NPs to eliminating ROS. In vivo, MSe-HA NPs after injection showed that simultaneously cured the local inflammation and sepsis induced with LPS by quickly eliminating excessive ROS. Especially in sepsis mouse models, the survival rate and the organic dysfunction significantly improved after treated with MSe-HA NPs. Thus, this novel mesoporous nanozyme provides an effective strategy for the design of nanomedicine and the treatment of inflammation-related diseases. (C) 2020 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available