Applications of single-drop microextraction in analytical chemistry: A review

Single-drop microextraction (SDME) has been recognized as one of the simple miniaturized sample preparation tools for the isolation and preconcentration of several analytes from a complex sample matrix. In this review, we explored the applications of SDME coupled with various analytical techniques (spectroscopy, chromatography, and mass spectrometry) for the analysis of organic molecules, inorganic ions, and biomolecules from various sample matrices including food, environmental, clinical, pharmaceutical, and industrial samples. Also, it summarizes the use of nanoparticles in SDME combined with various analytical tools for the rapid analysis of several trace-level target analytes. An overview of ionic liquids, deep eutectic solvents, and SUPRAS, which improved the selectivity and sensitivity of various analytical techniques toward several analytes, as promising extracting solvent systems in SDME is also included. Finally, discussed the impressive analytical features and future perspectives of SDME in this review article. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

SDME is recognized as a simple miniaturized sample preparation tool for the isolation and preconcentration of various analytes from complex sample matrices. The use of nanoparticles in SDME enables rapid analysis of trace-level target analytes. Introduction of new extracting solvent systems like ionic liquids, deep eutectic solvents, and SUPRAS improves the selectivity and sensitivity of various analytical techniques towards analytes.