Robust and Versatile Cu(I) metal frameworks as potential catalysts for azide-alkyne cycloaddition reactions: Review

The use of ?Click Reaction? for Cu(I) catalyzed azide?alkyne cycloaddition (CuAAC) has emerged as one of the most powerful tools for the synthesis of library of organic molecules having a wide range of applications. The approach is highly stereoselective that involves the formation of 1,4?disubstituted 1,2,3?triazole derivatives by the combination of diverse structural entities in the presence of Cu(I) as catalyst. There are numerous synthetic Cu (I) complexes with different ligands bound in diverse molecular framework with potential to act as catalyst to stitch organic azide to alkyne producing 1,4-di-substituted products. This review emphasizes on those versatile Cu (I) complexes having tailoring capability similar to those available commercially.

Automated summary

The Cu(I) catalyzed azide-alkyne cycloaddition using the "Click Reaction" is a highly stereoselective synthetic method for generating a library of organic molecules with diverse applications. Versatile Cu(I) complexes with tailoring capabilities can act as catalysts for forming 1,4-disubstituted products by stitching organic azide to alkyne.