Journal
ANIMALS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/ani11030691
Keywords
classical scrapie; atypical scrapie; prion disease; sheep; goat; review; surveillance; wasting disease
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Prion diseases, such as scrapie, are fatal neurodegenerative diseases caused by a conformational change from PrPC to PrPSc. Understanding the etiology, transmission pathways, tissue infectivity, and detection methods is crucial for disease control.
Prion diseases, such as scrapie, are neurodegenerative diseases with a fatal outcome, caused by a conformational change of the cellular prion protein (PrPC), originating with the pathogenic form (PrPSc). Classical scrapie in small ruminants is the paradigm of prion diseases, as it was the first transmissible spongiform encephalopathy (TSE) described and is the most studied. It is necessary to understand the etiological properties, the relevance of the transmission pathways, the infectivity of the tissues, and how we can improve the detection of the prion protein to encourage detection of the disease. The aim of this review is to perform an overview of classical and atypical scrapie disease in sheep and goats, detailing those special issues of the disease, such as genetic factors, diagnostic procedures, and surveillance approaches carried out in the European Union with the objective of controlling the dissemination of scrapie disease.
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