Journal
PROCESSES
Volume 9, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/pr9020353
Keywords
digital light processing; astragaloside; polyurethane; Schwann cells; anti-inflammatory
Categories
Funding
- Ministry of Science and Technology of Taiwan [MOST 109-2224-E-080-001, 109-2221-E-039-007]
- China Medical University of Taiwan [CMU109-S-25]
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This study successfully fabricated astragaloside-containing polyurethane nerve guidance conduits, demonstrating improved hydrophilicity and enhanced cellular proliferation, reduced inflammatory response, and increased neural regeneration markers.
The peripheral nervous system is the bridge of communication between the central nervous system and other body systems. Autologous nerve grafting is the mainstream method for repair of nerve lesions greater than 20 mm. However, there are several disadvantages and limitations of autologous nerve grafting, thus prompting the need for fabrication of nerve conduits for clinical use. In this study, we successfully fabricated astragaloside (Ast)-containing polyurethane (PU) nerve guidance conduits via digital light processing, and it was noted that the addition of Ast improved the hydrophilicity of traditional PU conduits by at least 23%. The improved hydrophilicity not only led to enhanced cellular proliferation of rat Schwann cells, we also noted that levels of inflammatory markers tumor necrosis factor-alpha (TNF-alpha) and cyclooxygenase-2 (COX-2) significantly decreased with increasing concentrations of Ast. Furthermore, the levels of neural regeneration markers were significantly enhanced with the addition of Ast. This study demonstrated that Ast-containing PU nerve conduits can be potentially used as an alternative solution to regenerate peripheral nerve injuries.
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