Journal
PHARMACEUTICS
Volume 13, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13020227
Keywords
glycolipids; nanocomposites; liposomes; antibacterial mechanism; anti-biofilm
Categories
Funding
- Public Projects of Zhejiang Province [LGF18C200003]
- National Key Research and Development Program of China [2018YFC1200100]
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Glycolipid biosurfactants are natural amphiphiles that have shown potential in combating microbial infections and preventing hospital infections, making them valuable in medical therapy for disease treatment and infection prevention.
Glycolipid biosurfactants are natural amphiphiles and have gained particular interest recently in their biodegradability, diversity, and bioactivity. Microbial infection has caused severe morbidity and mortality and threatened public health security worldwide. Glycolipids have played an important role in combating many diseases as therapeutic agents depending on the self-assembly property, the anticancer and anti-inflammatory properties, and the antimicrobial properties, including antibacterial, antifungal, and antiviral effects. Besides, their role has been highlighted as scavengers in impeding the biofilm formation and rupturing mature biofilm, indicating their utility as suitable anti-adhesive coating agents for medical insertional materials leading to a reduction in vast hospital infections. Notably, glycolipids have been widely applied to the synthesis of novel antimicrobial materials due to their excellent amphipathicity, such as nanoparticles and liposomes. Accordingly, this review will provide various antimicrobial applications of glycolipids as functional ingredients in medical therapy.
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