Journal
PHARMACEUTICS
Volume 13, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13030372
Keywords
anti-inflammatory drugs; biomaterials; controlled release; corticosteroid; degenerative joint disease
Categories
Funding
- Life Sciences Health (LSH) Impulse, (ArIADNE) [40-43100-98-022]
- Dutch Arthritis Society [LLP22, LLP12]
Ask authors/readers for more resources
This prospective study demonstrated the safety and proof-of-concept of IA-administered TA-PEAMs in treating OA pain and inflammation in dogs, showing potential for tissue regeneration.
Osteoarthritis (OA) is a common cause of pain and disability. Local corticosteroid injections are effective in treating OA pain and inflammation but are short-acting. Prolonged intra-articular (IA) corticosteroid exposure may even lead to cartilage deterioration. The aim of this prospective study was to assess safety and provide proof-of-concept of IA-applied biodegradable polyesteramide-based microspheres (PEAMs) gradually releasing triamcinolone acetonide (TA). Mimicking continuous exposure associated with local drug delivery in canine articular chondrocytes cultured in the continuous presence of TA tissue regeneration was not affected, whereas intermittent exposure reduced proteoglycan production. In this respect, TA-PEAMs administered IA in a proof-of-concept study in 12 client-owned dogs with established OA also showed safety by radiographic examination, without changes in OA severity and in glycosaminoglycan synovial fluid levels. Treatment also resulted in clinical improvement in 10 out of 11 dogs during the two-month follow-up period, which persisted in 6 out of 10 dogs after 6 months, based on objective gait analysis and owner questionnaires. Synovial prostaglandin E-2, a pro-inflammatory marker, was decreased two months after treatment. This study showed safety and proof-of-concept of IA-administered TA-PEAMs in dogs with OA, as a first step towards translation into the veterinary and human clinic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available