Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.553706
Keywords
circRNA; miRNA; tumor angiogenesis; VEGF; signaling pathways
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Funding
- National Natural Science Foundation of China [81400679]
- Guangdong Natural Science Foundation [2014A030310067]
- Guangzhou Science and Technology Programs [202002030387, 201704020153]
- Special fund of Foshan Summit plan [2019D006]
- Foundation of Basic and Applied Basic Research of Guangdong Province [2020A1515110073]
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CircRNAs play a crucial role in tumor angiogenesis and hold great potential for diagnosis and treatment of tumors, although the detailed biological regulatory mechanisms require further exploration.
Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5'-cap or a 3'-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.
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