Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.605988
Keywords
circRNA; breast cancer; cell proliferation; apoptosis; drug resistance; prognosis; biomarkers
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Funding
- National Natural Science Foundation of China [81902707]
- Hunan Provincial Natural Science Foundation [2018JJ6092, 2019JJ50537]
- Health and Family Planning Commission of Hunan Province [B2019120, B2019124, C2019114]
- Science and Technology Project of Hengyang [S2018F9031021272]
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CircRNAs, a new class of endogenous regulatory RNA molecules, play important roles in the initiation and progression of breast cancer, and have the potential to become new diagnostic and predictive biomarkers of breast cancer.
Recent statistics show that breast cancer is among the most frequent cancers in clinical practice. It is also the second-leading cause of cancer-related deaths among women worldwide. CircRNAs are a new class of endogenous regulatory RNA molecules whose 5' end and 3' end are connected together to form a covalently closed single-stranded loop by back-splicing. CircRNAs present the advantages of disease-specific expression and excellent expression stability, and they can modulate gene expression at posttranscriptional and transcriptional levels. CircRNAs are abnormally expressed in multiple cancers, such as breast cancer, and drive the initiation and progression of cancer. In this review, we describe current knowledge about the functions of circRNAs and generalize their roles in various aspects of breast cancer, including cell proliferation, cell cycle, apoptosis, invasion and metastasis, autophagy, angiogenesis, drug resistance, and tumor immunity, and their prognostic and diagnostic value. This may add to a better understanding of the functions and roles of circRNAs in breast cancer, which may become new diagnostic and predictive biomarkers of breast cancer.
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