4.6 Review

Mitophagy in Pancreatic Cancer

Related references

Note: Only part of the references are listed.
Article Cell Biology

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

Changfeng Li et al.

Summary: The study reveals that zalcitabine, an antiviral drug, can suppress pancreatic cancer cell growth through inducing ferroptosis, a type of cell death. This effect is mediated by zalcitabine-induced mitochondrial DNA stress and the activation of a DNA sensing pathway, leading to cell death via lipid peroxidation. Genetically or pharmacologically inhibiting this pathway reduces the anticancer effects of zalcitabine.

AUTOPHAGY (2021)

Review Oncology

Autophagy as a therapeutic target in pancreatic cancer

Max Piffoux et al.

Summary: PDAC is characterized by early metastasis and resistance to therapy, with mutations in KRAS and TP53 showing little clinical efficacy. Autophagy, upregulated in PDAC, plays a role in resistance to treatments, making it a potential therapeutic target. Combining inhibitors of the ERK/MAPK pathway with autophagy inhibitors has shown interesting results in PDAC models and other KRAS-driven cancers.

BRITISH JOURNAL OF CANCER (2021)

Article Gastroenterology & Hepatology

CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer

Jin Huang et al.

Summary: Inhibition of CDK1/2/5 kinase activity can overcome IFNG-mediated immune evasion in pancreatic tumors, turning a 'cold' tumor microenvironment into a 'hot' one and significantly improving overall survival rates in mouse pancreatic tumor models. Abnormal expression of CDK1/2/5 and IDO1 is associated with poor patient survival in various cancer types, including PDAC.
Review Cell Biology

Regulation and function of autophagy in pancreatic cancer

Jingbo Li et al.

Summary: Autophagy is a degradation system that can remove abnormal proteins and damaged organelles, with impaired autophagy being a pathological feature of diseases like pancreatic cancer. Dysfunctional autophagy plays a complex role in pancreatic tumor biology, with targeting selective autophagy potentially reducing side effects of drugs.

AUTOPHAGY (2021)

Review Oncology

Ferroptosis is a type of autophagy-dependent cell death

Borong Zhou et al.

SEMINARS IN CANCER BIOLOGY (2020)

Editorial Material Biotechnology & Applied Microbiology

Alkaliptosis: a new weapon for cancer therapy

Jiao Liu et al.

CANCER GENE THERAPY (2020)

Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Medicine, Research & Experimental

Glycolysis promotes the progression of pancreatic cancer and reduces cancer cell sensitivity to gemcitabine

Shangnan Dai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity

Sonia Alcala et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Keisuke Yamamoto et al.

NATURE (2020)

Review Cell Biology

Interplay Between Lipid Metabolism and Autophagy

Yangchun Xie et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING-dependent DNA sensor pathway

Enyong Dai et al.

NATURE COMMUNICATIONS (2020)

Review Cell Biology

Mitophagy Receptors in Tumor Biology

Yangchun Xie et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Autophagy-Dependent Ferroptosis: Machinery and Regulation

Jiao Liu et al.

CELL CHEMICAL BIOLOGY (2020)

Review Biology

The Role of Autophagy in Pancreatic Cancer-Recent Advances

Maria New et al.

BIOLOGY-BASEL (2020)

Article Biochemistry & Molecular Biology

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Kirsten L. Bryant et al.

NATURE MEDICINE (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Article Cell Biology

NIPSNAP1 and NIPSNAP2 Act as Eat Me Signals for Mitophagy

Yakubu Princely Abudu et al.

DEVELOPMENTAL CELL (2019)

Article Oncology

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer

Timothy J. Humpton et al.

CANCER DISCOVERY (2019)

Article Multidisciplinary Sciences

Clockophagy is a novel selective autophagy process favoring ferroptosis

Minghua Yang et al.

SCIENCE ADVANCES (2019)

Editorial Material Cell Biology

Autophagic degradation of the circadian clock regulator promotes ferroptosis

Jiao Liu et al.

AUTOPHAGY (2019)

Article Cell Biology

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

Sarbajeet Nagdas et al.

CELL REPORTS (2019)

Review Biochemistry & Molecular Biology

Biological Functions of Autophagy Genes: A Disease Perspective

Beth Levine et al.

Article Biochemistry & Molecular Biology

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer

Hyo Won Chang et al.

ONCOGENE (2019)

Article Medicine, Research & Experimental

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

Andrew M. Waters et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Article Biochemistry & Molecular Biology

Lipid metabolism and lipophagy in cancer

Meenu Maan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Editorial Material Biochemistry & Molecular Biology

Oncogene-induced senescence and tumour control in complex biological systems

Lorenzo Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Gastroenterology & Hepatology

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice

Xinxin Song et al.

GASTROENTEROLOGY (2018)

Review Cell Biology

Cargo recognition and degradation by selective autophagy

Damian Gatica et al.

NATURE CELL BIOLOGY (2018)

Review Cell Biology

Mechanism and medical implications of mammalian autophagy

Ivan Dikic et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Cell Biology

Building and decoding ubiquitin chains for mitophagy

J. Wade Harper et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors

Grace R. Anderson et al.

NATURE COMMUNICATIONS (2018)

Review Oncology

Targeted Therapies for Pancreatic Cancer

Idoroenyi Amanam et al.

CANCERS (2018)

Review Cell Biology

Autophagy-dependent cell death - where, how and why a cell eats itself to death

Shani Bialik et al.

JOURNAL OF CELL SCIENCE (2018)

Article Multidisciplinary Sciences

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter et al.

NATURE (2018)

Review Cell Biology

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Konstantinos Palikaras et al.

NATURE CELL BIOLOGY (2018)

Review Cell Biology

Selective Autophagy and Xenophagy in Infection and Disease

Vartika Sharma et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)

Review Cell Biology

Inflammatory signaling cascades and autophagy in cancer

Teresa Monkkonen et al.

AUTOPHAGY (2018)

Article Gastroenterology & Hepatology

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

Yangchun Xie et al.

GASTROENTEROLOGY (2017)

Review Oncology

Targeting autophagy in cancer

Jean M. Mulcahy Levy et al.

NATURE REVIEWS CANCER (2017)

Article Cell Biology

Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer

Rui Kang et al.

CELL RESEARCH (2017)

Article Biochemistry & Molecular Biology

FKBP8 recruits LC3A to mediate Parkin-independent mitophagy

Zambarlal Bhujabal et al.

EMBO REPORTS (2017)

Article Oncology

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells

Shan Zhu et al.

CANCER RESEARCH (2017)

Article Biochemistry & Molecular Biology

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Yongjie Wei et al.

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Review Biochemistry & Molecular Biology

p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation

Wei Jing Liu et al.

CELLULAR & MOLECULAR BIOLOGY LETTERS (2016)

Article Biochemistry & Molecular Biology

The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway

Raymonde Szargel et al.

HUMAN MOLECULAR GENETICS (2016)

Article Oncology

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation

Shenghong Yang et al.

CANCER IMMUNOLOGY RESEARCH (2016)

Article Multidisciplinary Sciences

Autophagy is required for PDAC glutamine metabolism

Ju-Won Seo et al.

SCIENTIFIC REPORTS (2016)

Article Cell Biology

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

Yuqing Wang et al.

AUTOPHAGY (2015)

Review Biochemistry & Molecular Biology

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

Yoshinori Katsuragi et al.

FEBS JOURNAL (2015)

Article Biochemistry & Molecular Biology

The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway

Feng Gao et al.

HUMAN MOLECULAR GENETICS (2015)

Article Multidisciplinary Sciences

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Michael Lazarou et al.

NATURE (2015)

Article Multidisciplinary Sciences

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

Tomokazu Murakawa et al.

NATURE COMMUNICATIONS (2015)

Article Medicine, Research & Experimental

HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice

Hikaru Ito et al.

EMBO MOLECULAR MEDICINE (2015)

Review Biochemistry & Molecular Biology

To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

Douglas R. Green et al.

Article Multidisciplinary Sciences

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

Yvette C. Wong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Biochemistry & Molecular Biology

Eat-Me: Autophagy, Phagocytosis, and Reactive Oxygen Species Signaling

Philip J. Vernon et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Oncology

Targeting apoptosis pathways in pancreatic cancer

Alexander Arlt et al.

CANCER LETTERS (2013)

Article Cell Biology

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase

Min Fu et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Article Multidisciplinary Sciences

p53 status determines the role of autophagy in pancreatic tumour development

Mathias T. Rosenfeldt et al.

NATURE (2013)

Article Oncology

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

Kristen M. Livesey et al.

CANCER RESEARCH (2012)

Article Multidisciplinary Sciences

The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia

Rui Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell Biology

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

Daolin Tang et al.

CELL METABOLISM (2011)

Article Multidisciplinary Sciences

Image-based genome-wide siRNA screen identifies selective autophagy factors

Anthony Orvedahl et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

Oxidative stress, inflammation, and cancer How are they linked?

Simone Reuter et al.

FREE RADICAL BIOLOGY AND MEDICINE (2010)

Article Cell Biology

Endogenous HMGB1 regulates autophagy

Daolin Tang et al.

JOURNAL OF CELL BIOLOGY (2010)

Article Cell Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler et al.

NATURE CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane

Urmi Bandyopadhyay et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Essential role for Nix in autophagic maturation of erythroid cells

Hector Sandoval et al.

NATURE (2008)