Journal
FRONTIERS IN ONCOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.615400
Keywords
glioblastoma; somatic mutation; neural stem cells; subventricular zone; genetically engineered mouse model
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Funding
- Suh Kyungbae Foundation
- Sovargen, Inc.
- National Research Foundation of Korea (NRF) - Korea government, Ministry of Science and ICT [2019R1A3B2066619]
- Daewoong Foundation
- National Research Foundation of Korea [2019R1A3B2066619] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study explores the pathogenesis and cell-of-origin of glioblastoma (GBM). It is suggested that GBM may originate from somatic mutations in neural stem cells and glial precursor cells. Further research will aid in understanding the evolution of GBMs and developing effective targets for treatment.
An aggressive primary brain cancer, glioblastoma (GBM) is the most common cancer of the central nervous system in adults. However, an inability to identify its cell-of-origin has been a fundamental issue hindering further understanding of the nature and pathogenesis of GBM, as well as the development of novel therapeutic targets. Researchers have hypothesized that GBM arises from an accumulation of somatic mutations in neural stem cells (NSCs) and glial precursor cells that confer selective growth advantages, resulting in uncontrolled proliferation. In this review, we outline genomic perspectives on IDH-wildtype and IDH-mutant GBMs pathogenesis and the cell-of-origin harboring GBM driver mutations proposed by various GBM animal models. Additionally, we discuss the distinct neurodevelopmental programs observed in either IDH-wildtype or IDH-mutant GBMs. Further research into the cellular origin and lineage hierarchy of GBM will help with understanding the evolution of GBMs and with developing effective targets for treating GBM cancer cells.
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