Journal
CELLS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells10030627
Keywords
lymphatic vessel; lymph node; anti-tumor immunity; metastasis
Categories
Funding
- NIH [R21AI097745, R01CA214913, R01HL128168, K00CA234940]
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The review focuses on the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes, and further spread to other distant organs. It discusses emerging molecular targets and potential strategies to inhibit lymph node metastasis.
Lymph nodes are the most common sites of metastasis in cancer patients. Nodal disease status provides great prognostic power, but how lymph node metastases should be treated is under debate. Thus, it is important to understand the mechanisms by which lymph node metastases progress and how they can be targeted to provide therapeutic benefits. In this review, we focus on delineating the process of cancer cell migration to and through lymphatic vessels, survival in draining lymph nodes and further spread to other distant organs. In addition, emerging molecular targets and potential strategies to inhibit lymph node metastasis are discussed.
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