Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be

Postmitotic cells, like neurons, must live through a lifetime. For this reason, organisms/cells have evolved with self-repair mechanisms that allow them to have a long life. The discovery workflow of neuroprotectors during the last years has focused on blocking the pathophysiological mechanisms that lead to neuronal loss in neurodegeneration. Unfortunately, only a few strategies from these studies were able to slow down or prevent neurodegeneration. There is compelling evidence demonstrating that endorsing the self-healing mechanisms that organisms/cells endogenously have, commonly referred to as cellular resilience, can arm neurons and promote their self-healing. Although enhancing these mechanisms has not yet received sufficient attention, these pathways open up new therapeutic avenues to prevent neuronal death and ameliorate neurodegeneration. Here, we highlight the main endogenous mechanisms of protection and describe their role in promoting neuron survival during neurodegeneration.

Automated summary

While most strategies in neuroprotective research only slow down or prevent neurodegeneration to a limited extent, enhancing cellular resilience by endorsing the self-healing mechanisms that organisms/cells inherently have can promote neuron self-healing and provide new therapeutic avenues for preventing neuronal death and ameliorating neurodegeneration.