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Ashu Johri et al.
NEURODEGENERATIVE DISEASES (2011)
The core human mitochondrial transcription initiation complex It only takes two to tango
Timothy E. Shutt et al.
TRANSCRIPTION-AUSTIN (2011)
MPTP Mouse Models of Parkinson's Disease: An Update
Gloria E. Meredith et al.
JOURNAL OF PARKINSONS DISEASE (2011)
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington's disease
Stephen J. McConoughey et al.
EMBO MOLECULAR MEDICINE (2010)
Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease
Jinho Kim et al.
HUMAN MOLECULAR GENETICS (2010)
Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation
Rajnish K. Chaturvedi et al.
HUMAN MOLECULAR GENETICS (2010)
Neuronal Inactivation of Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Protects Mice from Diet-induced Obesity and Leads to Degenerative Lesions
Di Ma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α
Elizabeth K. Lucas et al.
JOURNAL OF NEUROSCIENCE (2010)
p38 Mitogen-Activated Protein Kinase and Calcium Channels Mediate Signaling in Depolarization-Induced Activation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α in Neurons
Huan Ling Liang et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2010)
An Acetylation Switch Modulates the Transcriptional Activity of Estrogen-Related Receptor α
Brian J. Wilson et al.
MOLECULAR ENDOCRINOLOGY (2010)
A Double-Blind, Placebo-Controlled Study to Assess the Mitochondria-Targeted Antioxidant MitoQ as a Disease-Modifying Therapy in Parkinson's Disease
Barry J. Snow et al.
MOVEMENT DISORDERS (2010)
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Juan E. Belforte et al.
NATURE NEUROSCIENCE (2010)
NMDA Receptor Ablation on Parvalbumin-Positive Interneurons Impairs Hippocampal Synchrony, Spatial Representations, and Working Memory
Tatiana Korotkova et al.
NEURON (2010)
Variations of the CAG trinucleotide repeat in DNA polymerase gamma (POLG1) is associated with Parkinson's disease in Sweden
Anna Anvret et al.
NEUROSCIENCE LETTERS (2010)
Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1α enhances α-synuclein oligomerization and down regulates AKT/GSK3β signaling pathway in human neuronal cells that inducibly express α-synuclein
Abdul Shukkur Ebrahim et al.
NEUROSCIENCE LETTERS (2010)
Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility
E. H. Jeninga et al.
ONCOGENE (2010)
PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease
Bin Zheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Identification of novel targets for PGC-1α and histone deacetylase inhibitors in neuroblastoma cells
Rita M. Cowell et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Transcriptional coupling of synaptic transmission and energy metabolism: Role of nuclear respiratory factor 1 in co-regulating neuronal nitric oxide synthase and cytochrome c oxidase genes in neurons
Shilpa S. Dhar et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)
Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease
Rodrigo A. Quintanilla et al.
BRAIN RESEARCH BULLETIN (2009)
Mitochondrial structural and functional dynamics in Huntington's disease
P. Hemachandra Reddy et al.
BRAIN RESEARCH REVIEWS (2009)
Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease
Carmela Giampa et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Impaired PGC-1α function in muscle in Huntington's disease
Rajnish K. Chaturvedi et al.
HUMAN MOLECULAR GENETICS (2009)
Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair
Oliver Rothfuss et al.
HUMAN MOLECULAR GENETICS (2009)
PGC-1α and PGC-1β Regulate Mitochondrial Density in Neurons
Przemyslaw Wareski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
NMDA Receptor Dependent PGC-1α Up-Regulation Protects the Cortical Neuron Against Oxygen-Glucose Deprivation/Reperfusion Injury
Yun Luo et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2009)
Nuclear respiratory factor 1 co-regulates AMPA glutamate receptor subunit 2 and cytochrome c oxidase: tight coupling of glutamatergic transmission and energy metabolism in neurons
Shilpa S. Dhar et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Combination therapy with Coenzyme Q(10) and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's Diseases
Lichuan Yang et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Coupling of Energy Metabolism and Synaptic Transmission at the Transcriptional Level: Role of Nuclear Respiratory Factor 1 in Regulating both Cytochrome c Oxidase and NMDA Glutamate Receptor Subunit Genes
Shilpa S. Dhar et al.
JOURNAL OF NEUROSCIENCE (2009)
The gene coding for PGC-1α modifies age at onset in Huntington's Disease
Patrick Weydt et al.
MOLECULAR NEURODEGENERATION (2009)
PGC-1 alpha as modifier of onset age in Huntington disease
Elahe Taherzadeh-Fard et al.
MOLECULAR NEURODEGENERATION (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
Shu-ichi Okamoto et al.
NATURE MEDICINE (2009)
Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator
Richard C. Scarpulla
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Transcriptional control of mitochondrial biogenesis:: the central role of PGC-1α
Renee Ventura-Clapier et al.
CARDIOVASCULAR RESEARCH (2008)
Synergistic activation of the human MnSOD promoter by DJ-1 and PGC-1α: regulation by SUMOylation and oxidation
Nan Zhong et al.
HUMAN MOLECULAR GENETICS (2008)
Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry
Heike Runne et al.
JOURNAL OF NEUROSCIENCE (2008)
A Functional Interaction between RIP140 and PGC-1α Regulates the Expression of the Lipid Droplet Protein CIDEA
Magnus Hallberg et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease
Zena DeMarch et al.
NEUROBIOLOGY OF DISEASE (2008)
Transcriptional paradigms in mammalian mitochondrial biogenesis and function
Richard C. Scarpulla
PHYSIOLOGICAL REVIEWS (2008)
A Drosophila model for LRRK2-linked parkinsonism
Zhaohui Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mutant huntingtin and mitochondrial dysfunction
Ella Bossy-Wetzel et al.
TRENDS IN NEUROSCIENCES (2008)
Parkinson's disease and pesticides: a toxicological perspective
Jaime M. Hatcher et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Metabolic adaptations through the PGC-1α and SIRT1 pathways
Joseph T. Rodgers et al.
FEBS LETTERS (2008)
Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia
A. Christoforou et al.
MOLECULAR PSYCHIATRY (2007)
Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1α in cultured rat visual cortical neurons
Hui Meng et al.
BRAIN RESEARCH (2007)
Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
P. T. Luoma et al.
NEUROLOGY (2007)
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
Sibylle Jaeger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
Chiara Zuccato et al.
JOURNAL OF NEUROSCIENCE (2007)
Huntingtin interacting proteins are genetic modifiers of neurodegeneration
Linda S. Kaltenbach et al.
PLOS GENETICS (2007)
Localization of the transcriptional coactivator PGG-1α to GABAergic neurons during maturation of the rat brain
Rita Marie Cowell et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes
Petros Liodis et al.
JOURNAL OF NEUROSCIENCE (2007)
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Richard M. Reznick et al.
CELL METABOLISM (2007)
Mitochondria mass is low in mouse substantia nigra dopamine neurons: Implications for Parkinson's disease
Chang-Lin Liang et al.
EXPERIMENTAL NEUROLOGY (2007)
Functional consequences of mitochondrial proteome heterogeneity
D. Thor Johnson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Tissue heterogeneity of the mammalian mitochondrial proteome
D. Thor Johnson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity
Zena DeMarch et al.
NEUROBIOLOGY OF DISEASE (2007)
Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons
Mats I. Ekstrand et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
The 6-hydroxydopamine model of Parkinson's disease
Nicola Simola et al.
NEUROTOXICITY RESEARCH (2007)
Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1α in Huntington's disease neurodegeneration
Patrick Weydt et al.
CELL METABOLISM (2006)
Striatal specificity of gene expression dysregulation in Huntington's disease
Elizabeth A. Thomas
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
Julie St-Pierre et al.
CELL (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
Overexpression of peroxisome proliferator-activated receptor γ co-activator-1α leads to muscle atrophy with depletion of ATP
Shinji Miura et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice
Karen M. Smith et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
Populations of hippocampal inhibitory neurons express different levels of cytochrome c
Attila I. Gulyas et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease
AS Chen-Plotkin et al.
NEUROBIOLOGY OF DISEASE (2006)
Parkin enhances mitochondrial biogenesis in proliferating cells
Y Kuroda et al.
HUMAN MOLECULAR GENETICS (2006)
Nuclear control of respiratory gene expression in mammalian cells
RC Scarpulla
JOURNAL OF CELLULAR BIOCHEMISTRY (2006)
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
BN Finck et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptionaf response
Michael G. Rosenfeld et al.
GENES & DEVELOPMENT (2006)
Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival
J Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα:: a mechanism for transcriptional control of muscle glucose metabolism
AR Wende et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Paraquat neurotoxicity is distinct from that of MPTP and rotenone
JR Richardson et al.
TOXICOLOGICAL SCIENCES (2005)
Critical period plasticity in local cortical circuits
TK Hensch
NATURE REVIEWS NEUROSCIENCE (2005)
Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease
AA Li et al.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE (2005)
Mutant huntingtin represses CBP, but not p300, by binding and protein degradation
SY Cong et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2005)
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1α
C Handschin et al.
CELL (2005)
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease
BI Bae et al.
NEURON (2005)
Metabolic control through the PGC-1 family of transcription coactivators
JD Lin et al.
CELL METABOLISM (2005)
A developmental switch in the response of DRG neurons to ETS transcription factor signaling
S Hippenmeyer et al.
PLOS BIOLOGY (2005)
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
S Nemoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
The nuclear receptor coactivator PGC-1α exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1
A Bourdoncle et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
PGC-1α deficiency causes multi-system energy metabolic derangements:: Muscle dysfunction, abnormal weight control and hepatic steatosis
TC Leone et al.
PLOS BIOLOGY (2005)
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Z Arany et al.
CELL METABOLISM (2005)
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
JT Rodgers et al.
NATURE (2005)
Corepressors selectively control the transcriptional activity of PPARγ in adipocytes
HP Guan et al.
GENES & DEVELOPMENT (2005)
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β cactivation of SREBP
JD Lin et al.
CELL (2005)
PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3
SH Koo et al.
NATURE MEDICINE (2004)
Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner
LK Russell et al.
CIRCULATION RESEARCH (2004)
Huntingtin-protein interactions and the pathogenesis of Huntington's disease|
SH Li et al.
TRENDS IN GENETICS (2004)
Decreased cAMP response element-mediated transcription - An early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis
KL Sugars et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Clustering of DNA sequences in human promoters
PC FitzGerald et al.
GENOME RESEARCH (2004)
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress
S Prabakaran et al.
MOLECULAR PSYCHIATRY (2004)
Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor α (ERRα) -: Crystal structure of ERRα ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1α
J Kallen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Defects in adaptive energy metabolism with CNS-Linked hyperactivity in PGC-1α null mice
JD Lin et al.
CELL (2004)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
Caught in the act:: α-synuclein is the culprit in Parkinson's disease
JL Eriksen et al.
NEURON (2003)
The hunt for huntingtin function: interaction partners tell many different stories
P Harjes et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α):: Transcriptional coactivator and metabolic regulator
P Puigserver et al.
ENDOCRINE REVIEWS (2003)
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1 alpha
AE Wallberg et al.
MOLECULAR CELL (2003)
Genetic and environmental factors in the cause of Parkinson's disease
TT Warner et al.
ANNALS OF NEUROLOGY (2003)
Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis
S Goffart et al.
EXPERIMENTAL PHYSIOLOGY (2003)
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
LJ Borgius et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
J Lin et al.
NATURE (2002)
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
AW Dunah et al.
SCIENCE (2002)
Interaction of Huntington disease protein with transcriptional activator Sp1
SH Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Therapeutic effects of coenzyme Q(10) and remacemide in transgenic mouse models of Huntington's disease
RJ Ferrante et al.
JOURNAL OF NEUROSCIENCE (2002)
Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
R Bergeron et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2001)
PGC-1, a versatile coactivator
D Knutti et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2001)
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
JC Yoon et al.
NATURE (2001)
PGC-l-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells
U Andersson et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
CREB-binding protein and p300 in transcriptional regulation
N Vo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1
LF Michael et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Interference by Huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity
FC Nucifora et al.
SCIENCE (2001)
Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
JJ Lehman et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1
M Monsalve et al.
MOLECULAR CELL (2000)
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription
JS Steffan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Modulation of estrogen receptor-α transcriptional activity by the coactivator PGC-1
I Tcherepanova et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Expanded polyglutamine stretches interact with TAF(II)130, interfering with CREB-dependent transcription
T Shimohata et al.
NATURE GENETICS (2000)
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