Journal
CELLS
Volume 10, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/cells10030497
Keywords
pancreatic cancer; mitochondria; chemoresistance; metabolism; apoptosis
Categories
Funding
- National Natural Science Foundation of China [81772639, 81972258, 81974376]
- Natural Science Foundation of Beijing [7192157]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-001]
- National Fundamental Research Program of China [2018YFE0118600]
- Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019XK320001]
- MAECI (Executive Programme of Scientific and Technological Cooperation Italy-China 2019-2021) [CN19GR03]
- Fondo individuale FFABBR_NAT 2017 (MIUR, Italy)
- MIUR fellowship
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Mitochondria play important roles in the chemoresistance of pancreatic cancer by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Targeting certain factors in mitochondria may improve the sensitivity of pancreatic cancer cells to chemotherapeutic agents.
The first-line chemotherapies for patients with unresectable pancreatic cancer (PC) are 5-fluorouracil (5-FU) and gemcitabine therapy. However, due to chemoresistance the prognosis of patients with PC has not been significantly improved. Mitochondria are essential organelles in eukaryotes that evolved from aerobic bacteria. In recent years, many studies have shown that mitochondria play important roles in tumorigenesis and may act as chemotherapeutic targets in PC. In addition, according to recent studies, mitochondria may play important roles in the chemoresistance of PC by affecting apoptosis, metabolism, mtDNA metabolism, and mitochondrial dynamics. Interfering with some of these factors in mitochondria may improve the sensitivity of PC cells to chemotherapeutic agents, such as gemcitabine, making mitochondria promising targets for overcoming chemoresistance in PC.
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