Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/jcm10050989
Keywords
aquaporin 4; cerebral amyloid angiopathy; intracerebral hemorrhage; magnetic resonance imaging markers; functional outcome
Categories
Funding
- Instituto de Salud Carlos III (ISCIII) [PI17/00275, PI20/00465]
- European Regional Development Fund FEDER
- Neurovascular Research Laboratory is part of the INVICTUS+ network, ISCIII, Spain [RD16/0019/0021]
- Miguel Servet programme, ISCIII, Spain [CPII17/00010]
- Vall d'Hebron Research Institute
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Studies have shown that circulating levels of AQP4 are lower in patients with lobar intracerebral hemorrhage, and may be associated with hemorrhagic features and long-term functional outcomes.
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. Our aim was to investigate the circulating levels of AQP4 in a cohort of patients who had suffered a lobar ICH with a clinical diagnosis of CAA. AQP4 levels were analyzed in the serum of 60 CAA-related ICH patients and 19 non-stroke subjects by enzyme-linked immunosorbent assay (ELISA). The CAA-ICH cohort was divided according to the time point of the functional outcome evaluation: mid-term (12 +/- 18.6 months) and long-term (38.5 +/- 32.9 months) after the last ICH. Although no differences were found in AQP4 serum levels between cases and controls, lower levels were found in CAA patients presenting specific hemorrhagic features such as >= 2 lobar ICHs and >= 5 lobar microbleeds detected by magnetic resonance imaging (MRI). In addition, CAA-related ICH patients who presented a long-term good functional outcome had higher circulating AQP4 levels than subjects with a poor outcome or controls. Our data suggest that AQP4 could potentially predict a long-term functional outcome and may play a protective role after a lobar ICH.
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