4.7 Article

Renalase in Haemodialysis Patients with Chronic Kidney Disease

Journal

JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 4, Pages -

Publisher

MDPI
DOI: 10.3390/jcm10040680

Keywords

renalase; chronic kidney disease; haemodialysis

Funding

  1. program of the Minister of Science and Higher Education under the name Regional Initiative of Excellence in 2019-2022 [002/RID/2018/19]

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Levels of renalase in serum and urine were significantly elevated in haemodialysis CKD patients, while levels in erythrocytes were lower. Plasma concentrations of dopamine, adrenaline, and noradrenaline were also decreased in CKD patients. These changes may be related to compensatory production in extrarenal organs and altered degradation by plasma renalase.
Chronic kidney disease (CKD) is an inflammatory disease leading to kidney insufficiency and uremia. Renalase is a novel flavoprotein with enzymatic activities. Previous studies have shown that chronic kidney disease may influence renalase serum levels. Renalase metabolises catecholamines and therefore may be involved in the pathogenesis of hypertension and other diseases of the circulatory system. In this study, we examined renalase levels in serum, erythrocytes and urine from haemodialysis CKD patients. The study enrolled 77 haemodialysis CKD patients and 30 healthy subjects with normal kidney function as the control group. Renalase serum and urine concentrations in CKD patients were significantly increased when compared with control subjects (185.5 +/- 64.3 vs. 19.6 +/- 5.0 ng/mL; p < 0.00001 and 207.1 +/- 60.5 vs. 141.6 +/- 41.3 ng/mL; p = 0.00040, respectively). In contrast, renalase levels in erythrocytes were significantly lower in CKD patients when compared with control subjects (176.5 +/- 60.9 vs. 233.2 +/- 83.1 ng/mL; p = 0.00096). Plasma levels of dopamine, adrenaline and noradrenaline were also significantly lower in CKD patients when compared with controls. Conclusions: Increased serum and urine concentrations of renalase in haemodialysis CKD patients are likely related to compensatory production in extrarenal organs as a result of changes in the cardiovascular system and hypertension. The decreased plasma concentrations of catecholamines may be due to their increased degradation by plasma renalase. Decreased renalase levels in erythrocytes may be probably due to lower renalase synthesis by the kidneys in CKD. The results indicate the presence of renalase in erythrocytes.

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