4.8 Article

Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling

Journal

SCIENCE ADVANCES
Volume 7, Issue 7, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abf1798

Keywords

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Funding

  1. AMED [25463081, 17K118323, JP17nk0101334, JP20ek0109397]
  2. Kyoto University the fourth GAP Fund and Incubation Program
  3. Platform Project for Supporting Drug Discovery and Life Science Research [Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)] from AMED [19am0101075]

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Deficiency in USAG-1 leads to supernumerary teeth formation, while antibodies against USAG-1 can accelerate tooth development. Blocking USAG-1 function can alleviate congenital tooth agenesis caused by various genetic abnormalities.
Uterine sensitization-associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor-related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti-USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti-USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.

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