Journal
SCIENCE ADVANCES
Volume 7, Issue 6, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abd4074
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Funding
- National Key R&D Program of China [2019YFA0709501, 2018YFC1312900, 2019YFA0709502]
- National Natural Science Foundation of China [81801773, 91630314]
- Shanghai Pujiang Project [18PJ1400900]
- European Union [LSHM-CT-2007-037286]
- Horizon 2020 [695313]
- 111 Project [B18015]
- key project of Shanghai Science and Technology [16JC1420402]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- ERANID (Understanding the Interplay between Cultural, Biological and Subjective Factors in Drug Use Pathways) [PR-ST-0416-10004]
- Human Brain Project (HBP SGA 2) [785907]
- Medical Research Council Grant c-VEDA (Consortium on Vulnerability to Externalizing Disorders and Addictions) [MR/N000390/1]
- NIH [R01DA049238, 5U54EB020403-05, 1R56AG058854-01]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley N.H.S. Foundation Trust and King's College London
- Bundesministeriumfur Bildung und Forschung (BMBF) [01GS08152, 01EV0711, 01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1]
- Medical Research Foundation
- Medical Research Council [MR/R00465X/1, MR/S020306/1]
- ANR [ANR-12-SAMA-0004]
- Eranet Neuron (WM2NA) [AF12-NEUR0008-01]
- Fondation de France [00081242]
- Fondation pour la Recherche Medicale [DPA20140629802]
- Mission Interministerielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA)
- Assistance-Publique-Hopitaux-de-Paris
- Paris Sud University IDEX 2012
- Fondation de l'Avenir [AP-RM-17-013]
- Federation pour la Recherche sur le Cerveau
- NIH
- Science Foundation Ireland [16/ERCD/3797]
- USA (Axon, Testosterone and Mental Health during Adolescence) [RO1 MH085772-01A1]
- cross-NIH alliance
- NIH Consortium grant [U54 EB020403]
- ZJ Lab
- Human Brain Project (HBP SGA 3) [945539]
- ANR (AAPG2019, GeBra)
- Eranet Neuron (ADORe) [ANR-18-NEUR00002-01]
- INSERM
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Using neural imaging techniques, a study explored the neural network underlying alcoholism onset in adolescents. It identified a network centered on the medial orbitofrontal cortex, with evidence of inhibitory and excitatory coregulation by this region over the dorsal periaqueductal gray. Additionally, the study found significant relationships between baseline excitatory coregulation in this network and impulsivity, supporting the role of negative urgency in alcohol dependence.
Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.
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