4.8 Article

Myosin-driven actin-microtubule networks exhibit self-organized contractile dynamics

Journal

SCIENCE ADVANCES
Volume 7, Issue 6, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abe4334

Keywords

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Funding

  1. William M. Keck Foundation
  2. National Institutes of Health R15 Award (National Institute of General Medical Sciences) [R15GM123420]

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The cytoskeleton is a dynamic network of proteins that enables essential cellular processes, with microtubules providing flexural rigidity and enhanced connectivity to actin networks for self-organized myosin-driven contraction.
The cytoskeleton is a dynamic network of proteins, including actin, microtubules, and their associated motor proteins, that enables essential cellular processes such as motility, division, and growth. While actomyosin networks are extensively studied, how interactions between actin and microtubules, ubiquitous in the cytoskeleton, influence actomyosin activity remains an open question. Here, we create a network of co-entangled actin and microtubules driven by myosin II. We combine dynamic differential microscopy, particle image velocimetry, and particle tracking to show that both actin and microtubules undergo ballistic contraction with unexpectedly indistinguishable characteristics. This contractility is distinct from faster disordered motion and rupturing that active actin networks exhibit. Our results suggest that microtubules enable self-organized myosin-driven contraction by providing flexural rigidity and enhanced connectivity to actin networks. Beyond the immediate relevance to cytoskeletal dynamics, our results shed light on the design of active materials that can be precisely tuned by the network composition.

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