Journal
CHEM
Volume 7, Issue 2, Pages 421-435Publisher
CELL PRESS
DOI: 10.1016/j.chempr.2020.10.021
Keywords
-
Categories
Funding
- NSF [CHE1455017, CHE-2004217, MCB-1617025, DMR-1126894]
Ask authors/readers for more resources
This study extends the application of dynamic nuclear polarization technology by introducing endogenous metal centers for nuclear magnetic resonance enhancement. By tracing polarization transfer, the research deepens understanding of polarization pathways and expands the catalog of polarizing agents.
Dynamic nuclear polarization (DNP) harnesses the large polarization of electron spins to dramatically increase nuclear magnetic resonance (NMR) sensitivity. This study expands the scope of DNP beyond its traditional focus on hyperpolarizing the solvent network using exogenous polarizing agents (PAs). We introduce H-1 DNP with endogenous V4+ centers positioned in a set of vanadyl complexes with tunable V4+-H-1 distances. We traced the polarization transfer from V4+ to H-1 spins, specifically differentiating between direct V4+-(1)Hs polarization transfer and the H-1 spin-diffusion-mediated bulk solvent H-1 polarization buildup and illuminated the effect of the V4+-H-1 distance on these processes. These results deepen our understanding of polarization pathways and expand the catalog of PAs to broad-line transition metals. This study establishes crucial first steps toward employing strategically positioned endogenous paramagnetic metal centers for DNP and the conceptual framework of hyperfine DNP spectroscopy that merges both spatial and chemical diagnosis of target nuclear spins.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available