Synthetic Protocols for Aromatic Nitration: A Review

Nitration of aromatic compounds represents a powerful and widely used transformation that allows introducing nitro group into aromatic systems. New synthetic strategies for aromatic nitration are deeply needed, including highly efficient and selective nitration methods. Aromatic nitration plays an important part in the industry, as the main use of nitration is to produce important products such as dyes & intermediate compounds, drugs, and Agrochemicals. The electrophilic aromatic nitration is most studied and important transformation in industrial process. This review will describe different possible methodologies that apply to this fundamental transformation with special attention to the most recent development that lasted from 2017-2020. The main pros and cons of recent nitration methods are briefly described with their specific reaction mechanism and highlighting the most important feature of the present aromatic nitration method.

Automated summary

Nitration of aromatic compounds is a powerful and widely used transformation that allows introducing nitro group into aromatic systems. New synthetic strategies for aromatic nitration are needed for producing important products such as dyes & intermediate compounds, drugs, and Agrochemicals. The main focus is on the most recent developments in methodologies for aromatic nitration from 2017-2020, highlighting their pros and cons and specific reaction mechanisms.