Journal
CHEMISTRYSELECT
Volume 6, Issue 9, Pages 2036-2040Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202004150
Keywords
Deuteration; Diastereoselective; Spirocycle; Spiropyran; Water
Categories
Funding
- Science and Engineering Research Board, DST-SERB [EMR/2016/000317]
- SASTRA Deemed University
Ask authors/readers for more resources
Metal-free N-heterocyclic carbene (NHC) organocatalysis in D2O medium was elegantly used for the synthesis of highly diastereoselective deuterated spiropyran derivatives, achieving selective deuteration on the C5 carbon atom of the pyran ring and proving through quantum chemical calculations the preferential formation of a single diastereomer out of the possible four. The scope of NHC organocatalysis in D2O was further expanded for the synthesis of deuterated spirooxindole derivative.
Metal-free N-heterocyclic carbene (NHC) organocatalysis in D2O medium was elegantly utilised for the synthesis of highly diastereoselective deuterated spiropyran derivatives. Selective deuteration was exclusively achieved on the C5 carbon atom of the pyran ring. Quantum chemical calculations were performed to prove the preferential formation of a single diastereomer from the possible four diastereomers. The scope of NHC organocatalysis in D2O was also extended for the synthesis of deuterated spirooxindole derivative.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available