Journal
FOOD BIOSCIENCE
Volume 41, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fbio.2021.100935
Keywords
Bradykinin; Polyphenol-bradykinin interaction; Polyphenol role in pain
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Bradykinin and polyphenols may have a dual role in health; encapsulation of polyphenols could potentially reduce their binding affinity to bradykinin receptors, alleviating pain caused by bradykinin. This work falls within basic science, providing a potential biochemical mechanism of polyphenols' pharmacological action on pain sensation induced by bradykinin.
It can be deduced from this concise review that bradykinin and polyphenols could have a double role in health. Nevertheless, if their bioavailability is improved by their encapsulation, polyphenols could diminish the binding affinity of bradykinin to its receptors by causing a conformational rearrangement of the peptide. Besides, the interaction between polyphenols and bradykinin should play a role in pain. Indeed, the formation of the polyphenol-bradykinin aggregates might alleviate the pain sensation caused by bradykinin by preventing: the production of nitric oxide, the activation of phospholipase A(2), as well as that of nuclear factor-kappa B. To conclude, this work falls within the basic science, given that it seeks to provide a probable biochemical mechanism of the pharmacological action of polyphenols on the pain sensation caused by bradykinin.
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