Journal
COATINGS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/coatings11030324
Keywords
diabetes mellitus; diabetic wounds; Combretum molle; wound healing
Categories
Funding
- Taif University, Taif, Saudi Arabia [TURSP-2020/21]
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The study found that the extract of Combretum molle has significant antioxidant effects on oxidative stress in diabetic animal tissues and helps repair changes in the skin layers, promising great improvements for diabetic patients with foot ulcers.
Foot ulcers are one of the leading causes of severe and high mortality in diabetics. It is known that wound healing in diabetics is a very complicated process due to the direct severe effect of diabetes mellitus on blood vessels, causing difficulty in wound healing. Many methods of treatment have recently been employed for novel dressings for the promotion of tissue regeneration and rapid wound closure. Combretum molle is composed of chemical compounds, such as lignin, gallic acid, and ellagic acid. Twenty male rats that were 4 months of age were divided into a I-a diabetic foot ulcer group as the control group and a II-a diabetic group (wound + Combretum molle). This study investigated the antioxidant and excellent healing effects of the extract of Combretum molle in repairing skin damaged by diabetes. This was confirmed by elevated antioxidant enzymes in the animals' tissues in diabetic rats treated with this extract. The recovery of the alterations in the skin layers led to great improvements, which proved the Combretum molle's promising capacity for wound healing in diabetics with wounds that mimic diabetic foot ulcers. This treatment can be considered a promising opportunity for patients with severe foot ulcers and may open the door to more discoveries about this plant's medical capabilities.
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