Journal
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
Volume 10, Issue 3, Pages -Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/tvst.10.3.8
Keywords
retinal thickness; best-corrected visual acuity; the Raine Study; ganglion cell-inner plexiform layer; outer retinal layers
Categories
Funding
- Australian National Health and Medical Research Council (NHMRC) [GNT1021105]
- Ophthalmic Research Institute of Australia (ORIA)
- Alcon Research Institute
- Lions Eye Institute
- Australian Foundation for the Prevention of Blindness
- University of Western Australia
- Curtin University
- Telethon Kids Institute
- Women and Infants Research Foundation
- Edith Cowan University
- Murdoch University
- University of Notre Dame Australia
- Raine Medical Research Foundation
- NHMRC Early Career Fellowship
- Medical Research Future Fund Career Development Fellowship [MRF1142962]
- NHMRC Practitioner Fellowship
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The study mapped the thickness profiles of the full retinal and outer retinal layers in healthy young adults at the macula and found that increased thickness of the retina at the central macula was associated with better BCVA, although the effect size was small and not clinically significant.
Purpose: To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA). Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectral domain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths. Results: The median full retinal and ORL thicknesses at the central macula were 285 mu m and 92 mu m. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant. Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults. Translational Relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.
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