Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 8, Issue 2, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.201642
Keywords
glucopyanosyl-conjugated benzyl; colon cancer; HCT-116; 293T
Categories
Funding
- Natural Science Foundation of Xiaogan, China [XGKJ2019010046]
- Hubei University Excellent Young and Middle-Aged Science and Technology Innovation Team Project [T201816]
- Natural Science Foundation of Hubei Province, China [2014CFB570]
- National Natural Science Foundation of China [21503075, 81502022]
- Fundamental Research Fund for the Sun Yat-sen University [16ykpy35]
Ask authors/readers for more resources
A new glucopyranosyl-conjugated benzyl derivative containing a [1,2,3]-triazole linker was synthesized and showed potent antiproliferative activity against colorectal cancer cells, inducing apoptotic cell death.
Glucopyranosyl-conjugated benzyl derivatives containing a [1,2,3]-triazole linker were synthesized. Benzyl served as an important pharmacophore in anti-cancer compounds. Compound 8d inhibited the proliferation of colorectal cancer cells with the potency comparable to 5-fluorouracil (5-FU) with improved selectivity towards cancer cells. The antiproliferative activity of 8d is achieved through triggering apoptotic cell death.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
