Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2021.642568
Keywords
albumin; energy intake; feeding behavior; food intake; weight change; energy expenditure
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Funding
- Intramural Research Program of the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
- Intramural Research Program of the NIH, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- program Rita Levi Montalcini for young researchers
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The study found that lower serum albumin concentration was associated with greater daily energy intake and weight gain, suggesting albumin may be a marker of energy intake regulation.
Objective Circulating albumin is negatively associated with adiposity but whether it is associated with increased energy intake, lower energy expenditure or weight gain has not been examined. Methods In study 1 (n=238; 146 men), we evaluated whether fasting albumin concentration was associated with 24-h energy expenditure and ad libitum energy intake. In study 2 (n=325;167 men), we evaluated the association between plasma albumin and change in weight and body composition. Results After adjustment for known determinants of energy intake lower plasma albumin concentration was associated with greater total daily energy intake (beta= 89.8 kcal/day per 0.1 g/dl difference in plasma albumin, p=0.0047). No associations were observed between plasma albumin concentrations and 24-h energy expenditure or 24-h respiratory quotient (p>0.2). Over 6 years, volunteers gained on average 7.5 +/- 11.7 kg (p<0.0001). Lower albumin concentrations were associated with greater weight [beta=3.53 kg, p=0.039 (adjusted for age, sex, follow up time), CI 0.16 to 6.21 per 1 g/dl difference albumin concentration] and fat mass (beta=2.3 kg, p=0.022), respectively, but not with changes in fat free mass (p=0.06). Conclusions Lower albumin concentrations were associated with increased ad libitum food intake and weight gain, indicating albumin as a marker of energy intake regulation.
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