Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS. Under physiological conditions, apoptotic cells (ACs) could be effectively phagocytized and cleared by phagocyte-mediated efferocytosis. In contrast, the clearance efficiency of ACs in AS plaque was much lower because of the impaired efferocytosis in AS. Recent findings have made great progress on the molecular mechanisms of efferocytosis process and dynamic regulation, and its dysfunction on organismal health. Yet, there are still few effective treatments for this process. This article reviews the mechanism of efferocytosis and the role of efferocytosis in AS, highlighting a novel therapeutic strategy for AS, which mainly prevents the progression of plaque by targeting efferocytosis.

Automated summary

Atherosclerosis is the main pathological basis for cardio-cerebrovascular diseases, with abnormal accumulation of apoptotic and necrotic cells leading to plaque formation and rupture. The efficiency of phagocytosis of apoptotic cells in AS is low, and recent research has made progress in understanding the molecular mechanisms involved.