Journal
INFECTION AND DRUG RESISTANCE
Volume 14, Issue -, Pages 929-946Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S295798
Keywords
TB; immune status; diagnosis; TB-treatment; coinfections; personalized diagnosis
Categories
Funding
- National Institute for Respiratory Diseases Ismael Cosio Villegas
Ask authors/readers for more resources
Diagnosing tuberculosis in children is challenging due to the limitations of traditional microbiological techniques. New methods based on immune response may be influenced by various factors. Personalized diagnosis could improve treatment outcomes by evaluating specific molecules produced by the host immune response.
The diagnosis of tuberculosis (TB) in children is difficult because of the low sensitivity and specificity of traditional microbiology techniques in this age group. Whereas in adults the culture of Mycobacterium tuberculosis (M. tuberculosis), the gold standard test, detects 80% of positive cases, it only detects around 30-40% of cases in children. The new methods based on the immune response to M. tuberculosis infection could be affected by many factors. It is necessary to evaluate the medical record, clinical features, presence of drug-resistant M. tuberculosis strains, comorbidities, and BCG vaccination history for the diagnosis in children. There is no ideal biomarker for all TB cases in children. A new strategy based on personalized diagnosis could be used to evaluate specific molecules produced by the host immune response and make therapeutic decisions in each child, thereby changing standard immunological signatures to personalized signatures in TB. In this way, immune diagnosis, prognosis, and the use of potential immunomodulators as adjunct TB treatments will meet personalized treatment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available