Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.642975
Keywords
gene regulation; cardiac gene expression; transcription factor (TF); epigenomics and epigenetics; comparative genomics; enhancer
Categories
Funding
- Hospital for Sick Children Restracomp Studentship
- CIHR [FRN 156318]
- Canada Research Chairs Program
- Ontario Ministry of Research and Innovation
- Connaught International Scholarship
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Enhancers, crucial in controlling spatiotemporal gene expression profiles, are regulated by lineage-determining transcription factors and signaling effectors. Recent advancements in functional genomic technologies have led to unprecedented genome-wide annotation of heart enhancers and their target genes. Studying heart enhancers in various metazoan species has significantly contributed to our understanding of cardiac development and disease.
Bound by lineage-determining transcription factors and signaling effectors, enhancers play essential roles in controlling spatiotemporal gene expression profiles during development, homeostasis and disease. Recent synergistic advances in functional genomic technologies, combined with the developmental biology toolbox, have resulted in unprecedented genome-wide annotation of heart enhancers and their target genes. Starting with early studies of vertebrate heart enhancers and ending with state-of-the-art genome-wide enhancer discovery and testing, we will review how studying heart enhancers in metazoan species has helped inform our understanding of cardiac development and disease.
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