Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.638244
Keywords
colorectal cancer; Dicer; tRNA-derived fragments; epithelial-to-mesenchymal transition; hypoxia
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Funding
- National Natural Science Foundation of China [81672364, 81871917, 81802750]
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The study reveals that under hypoxia, Dicer1 plays a key role in colorectal cancer progression by mediating the invasion and migration of cancer cells through the regulation of a small non-coding RNA. This provides a new potential pathway for therapeutic interventions in inhibiting cancer progression.
Hypoxia plays a key role in colorectal cancer (CRC) metastasis, but its underlying mechanism remains largely unknown. Dicer1, an RNase, has been considered as a tumor regulator in many tumors. However, whether Dicer1 affects CRC progression under hypoxia remains uncertain. In this study, we found that Dicer1 expression was induced by hypoxia in CRC cells and it mediates hypoxia-induced CRC cell progression. Furthermore, we found that the expression of tRF-20-MEJB5Y13, a small non-coding RNA derived from tRNA, was increased under hypoxic conditions, and its upregulation by Dicer1 resulted in hypoxia-induced CRC cell invasion and migration. These results advance the current understanding of the role of Dicer1 in regulating hypoxia signals and provide a new pathway for the development of therapeutic interventions for inhibiting cancer progression.
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