Journal
FRONTIERS IN GENETICS
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2021.642444
Keywords
gene editing; Cas9; rabbit models; biomedical research; human diseases
Categories
Funding
- National Institutes of Health [R01CA47622, HHSN272201000020I, R01HL116546, R01HL147527, R01HL133162]
- Jake Gittlen Memorial Golf Tournament
- Parent Project Muscular Dystrophy award
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Gene-edited rabbit models offer unique opportunities in translational biomedical research due to their relatively large size and long lifespan compared to mouse models; they better mimic several disease pathologies, particularly in the fields of genetically inherited diseases, cardiovascular diseases, and ocular diseases.
The rabbit is a classic animal model for biomedical research, but the production of gene targeted transgenic rabbits had been extremely challenging until the recent advent of gene editing tools. More than fifty gene knockout or knock-in rabbit models have been reported in the past decade. Gene edited (GE) rabbit models, compared to their counterpart mouse models, may offer unique opportunities in translational biomedical research attributed primarily to their relatively large size and long lifespan. More importantly, GE rabbit models have been found to mimic several disease pathologies better than their mouse counterparts particularly in fields focused on genetically inherited diseases, cardiovascular diseases, ocular diseases, and others. In this review we present selected examples of research areas where GE rabbit models are expected to make immediate contributions to the understanding of the pathophysiology of human disease, and support the development of novel therapeutics.
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