Journal
MATERIALS & DESIGN
Volume 199, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.matdes.2020.109399
Keywords
Graphene oxide; Silicon-doped hydroxyapatite; In-situ grow; Co-dispersion nanosystem
Categories
Funding
- Natural Science Foundation of China [51935014, 82072084, 81871498]
- JiangXi Provincial Natural Science Foundation of China [20192ACB20005, 2020ACB214004, 20202BAB214011]
- Provincial Key R&D Projects of Jiangxi [20201BBE51012]
- Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme (2018)
- Project of Hunan Provincial Science and Technology Plan [2017RS3008]
- Shenzhen Science and Technology Plan Project [JCYJ20170817112445033]
- Innovation Team Project on University of Guangdong Province [2018GKCXTD001]
- Technology Innovation Platform Project of Shenzhen Institute of Information Technology 2020 [PT2020E002]
- Project of Science and technology of Jiangxi Provincial Education Department [GJJ190465]
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The study achieved a GO@Si-HA nanosystem by in-situ growth of Si-HA on GO, which was incorporated into a PLLA scaffold. The composite scaffold showed enhanced mechanical properties and superior bioactivity, making it a promising substitute for bone repairing.
Poly l-lactic acid (PLLA) was limited in the further orthopaedic application due to its insufficient mechanical property and poor bioactivity. Graphene oxide (GO) is an effective reinforcement, whereas silicon-doped hydroxyapatite (Si-HA) possesses excellent bioactivity, but either GO or Si-HA tends to aggregate in PLLA matrix. In this study, a GO@Si-HA nanosystem was achieved by in-situ growth of Si-HA on GO, and then incorporated into PLLA scaffold fabricated by laser sintering technology. On one hand, Si-HA on the surface of GO effectively prevented the aggregation of GO by acting as a barrier between GO nanosheets. On the other hand, GO hindered the aggregation of Si-HA by means of anchoring Si-HA. Results displayed that the compressive strength and modulus of the PLLA/GO@Si-HA composite scaffold were enhanced by 85% and 120%, respectively. Meanwhile, the scaffold exhibited significantly improved bioactivity, and consequently promoted cell adhesion, proliferation and differentiation. The developed PLLA/GO@Si-HA composite scaffold with excellent mechanical properties and superior bioactivity could serve as a promising substitute for bone repairing. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
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