4.4 Editorial Material

Late toxicities in non-Hodgkin lymphoma: extended follow-up matters

Related references

Note: Only part of the references are listed.
Article Hematology

Rituximab plus high-dose chemotherapy (MegaCHOEP) or conventional chemotherapy (CHOEP-14) in young, high-risk patients with aggressive B-cell lymphoma: 10-year follow-up of a randomised, open-label, phase 3 trial

Fabian Frontzek et al.

Summary: The study showed that there was no significant difference in event-free survival and overall survival between the R-MegaCHOEP and R-CHOEP-14 groups after 10 years of follow-up. High-dose chemotherapy and autologous hematopoietic stem cell transplantation did not improve outcomes in the R-MegaCHOEP group. Patients who relapsed with aggressive histology had a higher incidence of central nervous system involvement and poor prognosis, indicating a need for novel therapies.

LANCET HAEMATOLOGY (2021)