Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.635484
Keywords
natural polyphenols; colon cancer; targeted modulator; inflammation; microbe
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Funding
- Natural Science Foundation of China [31902168, 31872371]
- Young Elite Scientists Sponsorship Program by CAST [2019QNRC001]
- Huxiang Young Talents Plan Project of Hunan Province [2020RC3052]
- Guangdong Basic and Applied Basic Research Fund Project [2019A1515110852]
- National Science Foundation for Outstanding Young Scholars of Hunan Province [2019JJ30017]
- Hunan high-level talent gathering project [2018RS3111]
- Hunan Science and Technology Leading Talent Project [2019RS3022]
- Guangxi Key Research and Development Plan [guike AB19259012]
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Natural polyphenols, valued for their anti-inflammatory and antioxidant properties, have shown to play a key role in the prevention and treatment of colon cancer by maintaining a balance between gut microbes and hosts.
Colon cancer commonly develops from long-term chronic inflammation in the intestine and seriously threatens human health. Natural polyphenols have been valued as a crucial regulator of nutrient metabolism and metabolic diseases, owing to their anti-inflammatory and antioxidant functions and the ability to maintain a balance between gut microbes and their hosts. Notably, experimental and clinical evidence has shown that natural polyphenols could act as a targeted modulator to play a key role in the prevention or treatment of colon cancer. Thus, in this review, we summarized recent advances in the possible regulatory mechanism and the potential application of natural polyphenols in colon cancer, which might be regarded as a novel platform for the colon cancer management.
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