Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.626343
Keywords
pentraxins; autoimmunity; systemic lupus erythematosus; ANCA-associated vasculitis; anti-pentraxin autoantibodies
Categories
Funding
- LabEX IGO program (National Research Agency) [ANR-11-LABX-0016-01]
- University Hospital of Angers - University of Angers joint program (project 3I-Impact)
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Pentraxins are soluble innate immunity receptors that play a role in clearing microbes and dead cells, as well as regulating complement activation, inflammation, and tissue homeostasis. Autoantibodies against pentraxins are associated with autoimmune diseases like systemic lupus erythematosus and ANCA-associated vasculitis.
Pentraxins are soluble innate immunity receptors involved in sensing danger molecules. They are classified as short (CRP, SAP) and long pentraxin subfamilies, including the prototypic long pentraxin PTX3. Pentraxins act mainly as bridging molecules favoring the clearance of microbes and dead cells. They are also involved in many other biological processes, such as regulation of complement activation, inflammation and tissue homeostasis. Autoantibodies directed against pentraxins have been reported in various autoimmune diseases, especially in systemic lupus erythematosus and ANCA-associated vasculitis. In this review, we review the main biological characteristics and functions of pentraxins and summarize data concerning autoantibodies directed against pentraxins in the context of autoimmune diseases and discuss their potential pathological role.
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