Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.628576
Keywords
mitochondria; extracellular vesicles; immune cell; immunoregulation; mesenchymal stem cells
Categories
Funding
- Natural Science Foundation of Hunan Province in China [2019JJ40413]
- National Natural Science Foundation of China [82070758]
- Hunan Provincial Key R&D Program Project [2020SK2084]
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Mitochondria participate in immune regulation through various mechanisms, with recent studies showing the important effects of mitochondria from extracellular vesicles on immune regulation. Understanding the immunoregulatory effects of mitochondria from extracellular vesicles can shed light on underlying mechanisms.
Mitochondria participate in immune regulation through various mechanisms, such as changes in the mitochondrial dynamics, as metabolic mediators of the tricarboxylic acid cycle, by the production of reactive oxygen species, and mitochondrial DNA damage, among others. In recent years, studies have shown that extracellular vesicles are widely involved in intercellular communication and exert important effects on immune regulation. Recently, the immunoregulatory effects of mitochondria from extracellular vesicles have gained increasing attention. In this article, we review the mechanisms by which mitochondria participate in immune regulation and exert immunoregulatory effects upon delivery by extracellular vesicles. We also focus on the influence of the immunoregulatory effects of mitochondria from extracellular vesicles to further shed light on the underlying mechanisms.
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