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JOURNAL OF IMMUNOLOGY (2009)
Thymus-Blood Protein Interactions Are Highly Effective in Negative Selection and Regulatory T Cell Induction
Danielle F. Atibalentja et al.
JOURNAL OF IMMUNOLOGY (2009)
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett et al.
NATURE GENETICS (2009)
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn et al.
NATURE IMMUNOLOGY (2009)
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
Nicolas Fazilleau et al.
NATURE IMMUNOLOGY (2009)
Genetics of Type 1A Diabetes
Patrick Concannon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
CD28 Co-Stimulation Down Regulates Th17 Development
Salim Bouguermouh et al.
PLOS ONE (2009)
Non-obese diabetic mice select a low-diversity repertoire of natural regulatory T cells
Cristina Ferreira et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation
Robert J. Johnston et al.
SCIENCE (2009)
A Vital Role for Interleukin-21 in the Control of a Chronic Viral Infection
John S. Yi et al.
SCIENCE (2009)
IL-21R on T Cells Is Critical for Sustained Functionality and Control of Chronic Viral Infection
Anja Froehlich et al.
SCIENCE (2009)
The pancreas in human type 1 diabetes: providing new answers to age-old questions
Mark A. Atkinson et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2009)
Recurrence of autoreactive antigen-specific CD4+T cells in autoimmune diabetes after pancreas transplantation
Elsa Laughlin et al.
CLINICAL IMMUNOLOGY (2008)
Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice
Kevin S. Goudy et al.
CLINICAL IMMUNOLOGY (2008)
Intercellular MHC transfer between thymic epithelial and dendritic cells
Virginie Millet et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression
Sara A. Miller et al.
GENES & DEVELOPMENT (2008)
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
Qizhi Tang et al.
IMMUNITY (2008)
The Effector T Cells of Diabetic Subjects Are Resistant to Regulation via CD4+FOXP3+ Regulatory T Cells
Anya Schneider et al.
JOURNAL OF IMMUNOLOGY (2008)
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
Satoshi Serada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors
Anna Morena D'Alise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse
Rosanne Spolski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
How regulatory T cells work
Dario A. A. Vignali et al.
NATURE REVIEWS IMMUNOLOGY (2008)
Type 1 diabetes as a relapsing-remitting disease?
Matthias von Herrath et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes
Paolo Monti et al.
JOURNAL OF IMMUNOLOGY (2007)
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
Mary Rieck et al.
JOURNAL OF IMMUNOLOGY (2007)
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E. Lowe et al.
NATURE GENETICS (2007)
Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravis
Marte K. Viken et al.
HUMAN IMMUNOLOGY (2007)
Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor
Nikhil S. Joshi et al.
IMMUNITY (2007)
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
John A. Todd et al.
NATURE GENETICS (2007)
Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
M. Louise Markert et al.
BLOOD (2007)
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
Todd Brusko et al.
DIABETES (2007)
Transcription factors T-bet and Runx3 cooperate to activate lfng and silence ll4 in T helper type 1 cells
Ivana M. Djuretic et al.
NATURE IMMUNOLOGY (2007)
Natural regulatory T cells: mechanisms of suppression
Makoto Miyara et al.
TRENDS IN MOLECULAR MEDICINE (2007)
Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway
Brian T. Fife et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2006)
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
Roberto Bonasio et al.
NATURE IMMUNOLOGY (2006)
Role of PTPN22 in type 1 diabetes and other autoimmune diseases
Nunzio Bottini et al.
SEMINARS IN IMMUNOLOGY (2006)
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
T Vang et al.
NATURE GENETICS (2005)
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
AM Intlekofer et al.
NATURE IMMUNOLOGY (2005)
Follicular B helper T cells in antibody responses and autoimmunity
CG Vinuesa et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice
R Maehr et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Central tolerance: Learning self-control in the thymus
KA Hogquist et al.
NATURE REVIEWS IMMUNOLOGY (2005)
Type 1 diabetes - Evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families
P Concannon et al.
DIABETES (2005)
Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes
J Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Functional defects and the influence of age on the frequency of CD4+CD25+ T-Cells in type 1 diabetes
TM Brusko et al.
DIABETES (2005)
Signals from CD28 induce stable epigenetic modification of the IL-2 promoter
RM Thomas et al.
JOURNAL OF IMMUNOLOGY (2005)
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
JD Fontenot et al.
NATURE IMMUNOLOGY (2005)
Defective central tolerance induction in NOD mice: Genomics and genetics
S Zucchelli et al.
IMMUNITY (2005)
CD4+CD25high regulatory T cells in human autoimmune diabetes
AL Putnam et al.
JOURNAL OF AUTOIMMUNITY (2005)
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
S Lindley et al.
DIABETES (2005)
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
N Bottini et al.
NATURE GENETICS (2004)
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
K Hasegawa et al.
SCIENCE (2004)
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
J Gotter et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
D Smyth et al.
DIABETES (2004)
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
AM Gallegos et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2004)
What is the importance of the immunological synapse?
DM Davis et al.
TRENDS IN IMMUNOLOGY (2004)
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation
RA Seder et al.
NATURE IMMUNOLOGY (2003)
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
MJI Ansari et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
H Ueda et al.
NATURE (2003)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
JD Fontenot et al.
NATURE IMMUNOLOGY (2003)
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
A Sanchez-Fueyo et al.
NATURE IMMUNOLOGY (2003)
A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
S Anjos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Projection of an immunological self shadow within the thymus by the aire protein
MS Anderson et al.
SCIENCE (2002)
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
RS Wildin et al.
JOURNAL OF MEDICAL GENETICS (2002)
Genetics of type 1 diabetes mellitus
F Pociot et al.
GENES AND IMMUNITY (2002)
Polymorphisms in the gene encoding thymus-specific serine protease in the extended HLA complex: a potential candidate gene for autoimmune and HLA-associated diseases
BA Lie et al.
GENES AND IMMUNITY (2002)
T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells
M Afkarian et al.
NATURE IMMUNOLOGY (2002)
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes
V Viglietta et al.
JOURNAL OF CLINICAL INVESTIGATION (2002)
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
C Ramsey et al.
HUMAN MOLECULAR GENETICS (2002)
A defect in central tolerance in NOD mice
H Kishimoto et al.
NATURE IMMUNOLOGY (2001)
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
J Derbinski et al.
NATURE IMMUNOLOGY (2001)
Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
G Morahan et al.
NATURE GENETICS (2001)
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
RS Wildin et al.
NATURE GENETICS (2001)
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
ME Brunkow et al.
NATURE GENETICS (2001)
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
B Salomon et al.
IMMUNITY (2000)
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