Journal
FRONTIERS IN IMMUNOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.625034
Keywords
osteoimmunology; interleukin-17A; osteoclasts; osteoblasts; postmenopausal osteoporosis; rheumatoid arthritis; psoriatic arthritis; axial spondyloarthritis
Categories
Funding
- National Natural Science Foundation of China [81770875]
- Sichuan University [2018SCUH0093]
- Post-Doctor Research Project, West China Hospital, Sichuan University [19HXBH053]
- Health and Family Planning Commission of Sichuan Province [19PJ096]
- 1.3.5 project for discipline of excellence, West China Hospital, Sichuan University [2020HXFH008, ZYJC18003]
- National Clinical Research Center for Geriatrics of West China Hospital [Z2018B05]
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The interaction between the immune and skeletal systems is crucial for maintaining skeletal homeostasis, with IL-17A playing a key role; IL-17A has dual effects on osteoclasts and osteoblasts, and is involved in immune-mediated bone diseases; Understanding the pathophysiological roles of IL-17A may offer potential strategies for treating immune-mediated bone diseases.
The complex crosstalk between the immune and the skeletal systems plays an indispensable role in the maintenance of skeletal homeostasis. Various cytokines are involved, including interleukin (IL)-17A. A variety of immune and inflammatory cells produces IL-17A, especially Th17 cells, a subtype of CD4(+) T cells. IL-17A orchestrates diverse inflammatory and immune processes. IL-17A induces direct and indirect effects on osteoclasts. The dual role of IL-17A on osteoclasts partly depends on its concentrations and interactions with other factors. Interestingly, IL-17A exerts a dual role in osteoblasts in vitro. IL-17A is a bone-destroying cytokine in numerous immune-mediated bone diseases including postmenopausal osteoporosis (PMOP), rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondylarthritis (axSpA). This review will summarize and discuss the pathophysiological roles of IL-17A on the skeletal system and its potential strategies for application in immune-mediated bone diseases.
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