4.8 Review

Emerging Perspectives of RNA N6-methyladenosine (m6A) Modification on Immunity and Autoimmune Diseases

Journal

FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.630358

Keywords

N-6-methyladenosine (m(6)A); innate immunity; adaptive immunity; autoimmune disease; viral infection

Categories

Funding

  1. Innovative and Enhancement Research Program of Guangdong Province [2019KTSCX025]
  2. Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine [YN2018QJ03]
  3. Medical Scientific Research Foundation of Guangdong Province [A2017277]
  4. Specific Fund of State Key Laboratory of Dampness Syndrome of Chinese Medicine [SZ2020ZZ27]

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N-6-methyladenosine modification is one of the most prevalent chemical modifications in RNA, influencing gene expression by modulating RNA metabolism. Recent studies suggest its critical modulatory effects on immunity, viral infection, and autoimmune diseases, providing potential biomarkers and therapeutic targets for viral infection and autoimmune disorders.
N-6-methyladenosine (m(6)A) modification, the addition of a methylation decoration at the position of N6 of adenosine, is one of the most prevalent modifications among the over 100 known chemical modifications of RNA. Numerous studies have recently characterized that RNA m(6)A modification functions as a critical post-transcriptional regulator of gene expression through modulating various aspects of RNA metabolism. In this review, we will illustrate the current perspectives on the biological process of m(6)A methylation. Then we will further summarize the vital modulatory effects of m(6)A modification on immunity, viral infection, and autoinflammatory disorders. Recent studies suggest that m(6)A decoration plays an important role in immunity, viral infection, and autoimmune diseases, thereby providing promising biomarkers and therapeutic targets for viral infection and autoimmune disorders.

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