Arthropods Under Pressure: Stress Responses and Immunity at the Pathogen-Vector Interface

Understanding what influences the ability of some arthropods to harbor and transmit pathogens may be key for controlling the spread of vector-borne diseases. Arthropod immunity has a central role in dictating vector competence for pathogen acquisition and transmission. Microbial infection elicits immune responses and imparts stress on the host by causing physical damage and nutrient deprivation, which triggers evolutionarily conserved stress response pathways aimed at restoring cellular homeostasis. Recent studies increasingly recognize that eukaryotic stress responses and innate immunity are closely intertwined. Herein, we describe two well-characterized and evolutionarily conserved mechanisms, the Unfolded Protein Response (UPR) and the Integrated Stress Response (ISR), and examine evidence that these stress responses impact immune signaling. We then describe how multiple pathogens, including vector-borne microbes, interface with stress responses in mammals. Owing to the well-conserved nature of the UPR and ISR, we speculate that similar mechanisms may be occurring in arthropod vectors and ultimately impacting vector competence. We conclude this Perspective by positing that novel insights into vector competence will emerge when considering that stress-signaling pathways may be influencing the arthropod immune network.

Automated summary

Understanding the factors influencing the ability of arthropods to host and transmit pathogens is crucial for controlling vector-borne diseases. Arthropod immunity plays a central role in determining vector competence for pathogen acquisition and transmission, with immune responses triggered by microbial infections and stress on the host. Recent studies suggest a close connection between eukaryotic stress responses and innate immunity, with mechanisms such as the Unfolded Protein Response (UPR) and Integrated Stress Response (ISR) impacting immune signaling and potentially affecting vector competence in arthropods.